3-Ethenyl-2-(4-methoxyphenyl)-3H-naphtho[1,2-D]imidazole

Base Information

• Chemical Name: 3-Ethenyl-2-(4-methoxyphenyl)-3H-naphtho[1,2-D]imidazole
• CAS No.: 81288-62-2
• Molecular Formula: C20H16N2O
• Molecular Weight: 300.36
• ChEMBL ID: CHEMBL156398
• DSSTox Substance ID: DTXSID70607828
• Wikidata: Q82506909

Synonyms:81288-62-2;CHEMBL156398;SCHEMBL11024220;DTXSID70607828;3-ETHENYL-2-(4-METHOXYPHENYL)-3H-NAPHTHO[1,2-D]IMIDAZOLE

Chemical Property of 3-Ethenyl-2-(4-methoxyphenyl)-3H-naphtho[1,2-D]imidazole

Chemical Property:

• XLogP3: 4.9
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 3
• Exact Mass: 300.126263138
• Heavy Atom Count: 23
• Complexity: 418

Purity/Quality:

85.0-99.8% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC=C(C=C1)C2=NC3=C(N2C=C)C=CC4=CC=CC=C43

Technology Process of 3-Ethenyl-2-(4-methoxyphenyl)-3H-naphtho[1,2-D]imidazole

There total 7 articles about 3-Ethenyl-2-(4-methoxyphenyl)-3H-naphtho[1,2-D]imidazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-(2-chloroethyl)-2-(4-methoxyphenyl)-3H-naphth<1,2-d>imidazole (81288-64-4) → 3-ethenyl-2-(4-methoxyphenyl)-3H-naphth[1,2-d]imidazole (81288-62-2)

Guidance literature:

With sodium hydride; In N,N-dimethyl-formamide; at 60 ℃; for 2.5h; Yield given;

DOI:10.1021/jm00371a010

Reference yield:

1-Amino-2-(2-hydroxyethylamino)-naphthalin (62225-49-4) → 3-ethenyl-2-(4-methoxyphenyl)-3H-naphth[1,2-d]imidazole (81288-62-2)

Guidance literature:

Multi-step reaction with 4 steps

1: toluene / 3 h / Heating

2: 5percent Pd/C / toluene / 2 h / Heating

3: thionyl chloride / CHCl₃ / 0.33 h / Heating

4: NaH / dimethylformamide / 2.5 h / 60 °C

With thionyl chloride; sodium hydride; palladium on activated charcoal; In chloroform; N,N-dimethyl-formamide; toluene;

DOI:10.1021/jm00371a010

Reference yield:

4-methoxy-benzaldehyde (123-11-5) → 3-ethenyl-2-(4-methoxyphenyl)-3H-naphth[1,2-d]imidazole (81288-62-2)

Guidance literature:

Multi-step reaction with 4 steps

1: toluene / 3 h / Heating

2: 5percent Pd/C / toluene / 2 h / Heating

3: thionyl chloride / CHCl₃ / 0.33 h / Heating

4: NaH / dimethylformamide / 2.5 h / 60 °C

With thionyl chloride; sodium hydride; palladium on activated charcoal; In chloroform; N,N-dimethyl-formamide; toluene;

DOI:10.1021/jm00371a010

upstream raw materials:

3-(2-chloroethyl)-2-(4-methoxyphenyl)-3H-naphth<1,2-d>imidazole

1-Amino-2-(2-hydroxyethylamino)-naphthalin

4-methoxy-benzaldehyde

N-(2-hydroxyethyl)-1-nitroso-2-naphthalenamine

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