6-(2,4-Difluorophenoxy)-2,3-dihydro-1H-inden-5-amine

Base Information

• Chemical Name: 6-(2,4-Difluorophenoxy)-2,3-dihydro-1H-inden-5-amine
• CAS No.: 81614-79-1
• Molecular Formula: C15H13F2NO
• Molecular Weight: 261.271
• DSSTox Substance ID: DTXSID90512344
• Wikidata: Q82371539
• Mol file: 81614-79-1.mol

Synonyms:6-(2,4-Difluorophenoxy)-2,3-dihydro-1H-inden-5-amine;81614-79-1;SCHEMBL10943638;DTXSID90512344;FPKWQCUOBUOMPA-UHFFFAOYSA-N;6-(2,4-difluorophenoxy)-5-indanylamine

Chemical Property of 6-(2,4-Difluorophenoxy)-2,3-dihydro-1H-inden-5-amine

Chemical Property:

• XLogP3: 3.8
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 2
• Exact Mass: 261.09652036
• Heavy Atom Count: 19
• Complexity: 315

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CC2=CC(=C(C=C2C1)OC3=C(C=C(C=C3)F)F)N

Technology Process of 6-(2,4-Difluorophenoxy)-2,3-dihydro-1H-inden-5-amine

There total 7 articles about 6-(2,4-Difluorophenoxy)-2,3-dihydro-1H-inden-5-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

5-(2,4-difluorophenoxy)-6-nitroindan (81614-72-4) → 6-(2,4-difluorophenoxy)-5-indanylamine (81614-79-1)

Guidance literature:

With hydrogen; nickel; In methanol; for 4h; under 52504.2 Torr;

Reference yield:

indan-5-amine (24425-40-9) → 6-(2,4-difluorophenoxy)-5-indanylamine (81614-79-1)

Guidance literature:

Multi-step reaction with 4 steps

1: 50 percent / cc H₂SO₄, HNO₃ / 1./ 0.5 h. 2./ 1 h. room temp.

2: 1./ cc H₂SO₄, NaNO₂, acetic acid, 2./ CuBr, NaBr, 16percent HBr / 1./ water, 1 h. 3-5 deg C_.

3: 38 percent / CuCl, potassium tert-butoxide / 2-methyl-propan-2-ol / 7 h / Heating

4: 100 percent / H₂ / Raney-nickel / methanol / 4 h / 52504.2 Torr

With sulfuric acid; potassium tert-butylate; hydrogen bromide; hydrogen; nitric acid; acetic acid; sodium bromide; copper(l) chloride; copper(I) bromide; sodium nitrite; nickel; In methanol; tert-butyl alcohol;

Reference yield:

5-bromoindane (6134-54-9) → 6-(2,4-difluorophenoxy)-5-indanylamine (81614-79-1)

Guidance literature:

Multi-step reaction with 3 steps

1: 37 percent / HNO₃ / 0.25 h / 0 - 5 °C

2: 38 percent / CuCl, potassium tert-butoxide / 2-methyl-propan-2-ol / 7 h / Heating

3: 100 percent / H₂ / Raney-nickel / methanol / 4 h / 52504.2 Torr

With potassium tert-butylate; hydrogen; nitric acid; copper(l) chloride; nickel; In methanol; tert-butyl alcohol;

upstream raw materials:

5-(2,4-difluorophenoxy)-6-nitroindan

indan-5-amine

5-bromoindane

5-amino-6-nitroindane

Downstream raw materials:

5-acetylamino-6-(2,4-difluorophenoxy)-1-indanone

N-[6-(2,4-difluorophenoxy)-5-indanyl]methanesulfonamide

flosulide

5-amino-6-(2,4-difluorophenoxy)-1-indanone