N-(6-(2,4-difluorophenoxy)indan-5-yl)methanesulfonamide

Base Information

• Chemical Name: N-(6-(2,4-difluorophenoxy)indan-5-yl)methanesulfonamide
• CAS No.: 81614-86-0
• Molecular Formula: C16H15F2NO3S
• Molecular Weight: 0
• Mol file: 81614-86-0.mol

Synonyms:N-(6-(2,4-Difluorophenoxy)indan-5-yl)methanesulfonamide;N-[6-(2,4-difluorophenoxy)-5-indanyl]methanesulfonamide;6-Dfpims;N-(6-(2,4-Difluorophenoxy)-2,3-dihydro-1H-inden-5-yl)methanesulfonamide;

Chemical Property of N-(6-(2,4-difluorophenoxy)indan-5-yl)methanesulfonamide

Chemical Property:

• Vapor Pressure: 1.74E-06mmHg at 25°C
• Boiling Point: 396.2°C at 760 mmHg
• Flash Point: 193.4°C
• PSA: 63.78000
• Density: 1.425g/cm³
• LogP: 4.77110

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-(6-(2,4-difluorophenoxy)indan-5-yl)methanesulfonamide

There total 7 articles about N-(6-(2,4-difluorophenoxy)indan-5-yl)methanesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

methanesulfonyl chloride (124-63-0) + 6-(2,4-difluorophenoxy)-5-indanylamine (81614-79-1) → N-[6-(2,4-difluorophenoxy)-5-indanyl]methanesulfonamide (81614-86-0)

Guidance literature:

With pyridine; 1./ 3 h. 0 deg C_. 2./ room temp.;

Reference yield:

indan-5-amine (24425-40-9) → N-[6-(2,4-difluorophenoxy)-5-indanyl]methanesulfonamide (81614-86-0)

Guidance literature:

Multi-step reaction with 5 steps

1: 50 percent / cc H₂SO₄, HNO₃ / 1./ 0.5 h. 2./ 1 h. room temp.

2: 1./ cc H₂SO₄, NaNO₂, acetic acid, 2./ CuBr, NaBr, 16percent HBr / 1./ water, 1 h. 3-5 deg C_.

3: 38 percent / CuCl, potassium tert-butoxide / 2-methyl-propan-2-ol / 7 h / Heating

4: 100 percent / H₂ / Raney-nickel / methanol / 4 h / 52504.2 Torr

5: 76 percent / pyridine / 1./ 3 h. 0 deg C_. 2./ room temp.

With pyridine; sulfuric acid; potassium tert-butylate; hydrogen bromide; hydrogen; nitric acid; acetic acid; sodium bromide; copper(l) chloride; copper(I) bromide; sodium nitrite; nickel; In methanol; tert-butyl alcohol;

Reference yield:

5-bromoindane (6134-54-9) → N-[6-(2,4-difluorophenoxy)-5-indanyl]methanesulfonamide (81614-86-0)

Guidance literature:

Multi-step reaction with 4 steps

1: 37 percent / HNO₃ / 0.25 h / 0 - 5 °C

2: 38 percent / CuCl, potassium tert-butoxide / 2-methyl-propan-2-ol / 7 h / Heating

3: 100 percent / H₂ / Raney-nickel / methanol / 4 h / 52504.2 Torr

4: 76 percent / pyridine / 1./ 3 h. 0 deg C_. 2./ room temp.

With pyridine; potassium tert-butylate; hydrogen; nitric acid; copper(l) chloride; nickel; In methanol; tert-butyl alcohol;

upstream raw materials:

methanesulfonyl chloride

6-(2,4-difluorophenoxy)-5-indanylamine

indan-5-amine

5-bromoindane