Spiro[bicyclo[3.1.0]hexane-2,4'-oxazolidine]-3',6-dicarboxylic acid, 3-[(3,4-dichlorophenyl)methoxy]-6-fluoro-5'-oxo-, 6-[2-(diethylamino)-2-oxoethyl] 3'-(2-propenyl) ester, (1R,2R,3R,5R,6R)-

Base Information

• Chemical Name: Spiro[bicyclo[3.1.0]hexane-2,4'-oxazolidine]-3',6-dicarboxylic acid, 3-[(3,4-dichlorophenyl)methoxy]-6-fluoro-5'-oxo-, 6-[2-(diethylamino)-2-oxoethyl] 3'-(2-propenyl) ester, (1R,2R,3R,5R,6R)-
• CAS No.: 820244-81-3
• Molecular Formula: C26H29Cl2FN2O8
• Molecular Weight: 587.429

Synonyms:

Chemical Property of Spiro[bicyclo[3.1.0]hexane-2,4'-oxazolidine]-3',6-dicarboxylic acid, 3-[(3,4-dichlorophenyl)methoxy]-6-fluoro-5'-oxo-, 6-[2-(diethylamino)-2-oxoethyl] 3'-(2-propenyl) ester, (1R,2R,3R,5R,6R)-

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MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Spiro[bicyclo[3.1.0]hexane-2,4'-oxazolidine]-3',6-dicarboxylic acid, 3-[(3,4-dichlorophenyl)methoxy]-6-fluoro-5'-oxo-, 6-[2-(diethylamino)-2-oxoethyl] 3'-(2-propenyl) ester, (1R,2R,3R,5R,6R)-

There total 1 articles about Spiro[bicyclo[3.1.0]hexane-2,4'-oxazolidine]-3',6-dicarboxylic acid, 3-[(3,4-dichlorophenyl)methoxy]-6-fluoro-5'-oxo-, 6-[2-(diethylamino)-2-oxoethyl] 3'-(2-propenyl) ester, (1R,2R,3R,5R,6R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(1'R,2'R,3'R,5'R,6'R)-3'-(3,4-dichlorobenzyloxy)-6'-fluoro-3-allyloxycarbonyl-5-oxooxazinone-4-spiro-2'-bicyclo[3.1.0]hexane-6'-carboxylic acid (820244-80-2) + 2-Chloro-N,N-diethylacetamide (2315-36-8) → (1'R,2'R,3'R,5'R,6'R)-3'-(3,4-dichlorobenzyloxy)-6'-fluoro-3-allyloxycarbonyl-5-oxo-oxazolidinone-4-spiro-2'-bicyclo[3.1.0]hexane-6'-carboxylate 6-(N,N-diethylaminocarbonylmethyl) ester (820244-81-3)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 15h;

Reference yield:

(1'R,2'R,3'R,5'R,6'R)-3'-(3,4-dichlorobenzyloxy)-6'-fluoro-3-allyloxycarbonyl-5-oxo-oxazolidinone-4-spiro-2'-bicyclo[3.1.0]hexane-6'-carboxylate 6-(N,N-diethylaminocarbonylmethyl) ester (820244-81-3) → (1R,2R,3S,5R,6R)-2-amino-3-(3,4-dichlorobenzyloxy)-6-fluorobicyclo[3.1.0]hexane-2,6-carboxylic acid 6-(N,N-diethylaminocarbonylmethyl) ester

Guidance literature:

With 1,3-dimethylbarbituric acid; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In chloroform; at 40 ℃; for 1.5h;

upstream raw materials:

(1'R,2'R,3'R,5'R,6'R)-3'-(3,4-dichlorobenzyloxy)-6'-fluoro-3-allyloxycarbonyl-5-oxooxazinone-4-spiro-2'-bicyclo[3.1.0]hexane-6'-carboxylic acid

2-Chloro-N,N-diethylacetamide

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