Technology Process of 1,3-Dioxolane,
2-[5-[(2-ethynyl-5-methoxyphenyl)methoxy]-3-pentynyl]-2-(1-methylethen
yl)-
There total 11 articles about 1,3-Dioxolane,
2-[5-[(2-ethynyl-5-methoxyphenyl)methoxy]-3-pentynyl]-2-(1-methylethen
yl)- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
N,N,N,N,N,N-hexamethylphosphoric triamide; n-butyllithium;
In
tetrahydrofuran;
at 21 ℃;
for 2h;
DOI:10.1021/jo00139a012
- Guidance literature:
-
Multi-step reaction with 6 steps
1: pyridinium chlorochromate, sodium acetate / CH2Cl2 / 1.5 h
2: tetrahydrofuran; diethyl ether / -78 °C
3: 86 percent / pyridinium chlorochromate, sodium acetate / CH2Cl2 / 1.5 h
4: 52 percent / p-toluenesulfonic acid / 7 h / Heating
5: 1.) n-butyllithium / 1.) THF, hexane, -78 deg C 2.) THF, hexane, 0 deg C
6: 1.) n-butyllithium, HMPA / 1.)THF, hexane, -78 degC to 0 degC 2.) 45-50 degC, 2 h
With
N,N,N,N,N,N-hexamethylphosphoric triamide; n-butyllithium; sodium acetate; pyridinium chlorochromate;
toluene-4-sulfonic acid;
In
tetrahydrofuran; diethyl ether; dichloromethane;
DOI:10.1021/jo00183a018
- Guidance literature:
-
Multi-step reaction with 5 steps
1: tetrahydrofuran; diethyl ether / -78 °C
2: 86 percent / pyridinium chlorochromate, sodium acetate / CH2Cl2 / 1.5 h
3: 52 percent / p-toluenesulfonic acid / 7 h / Heating
4: 1.) n-butyllithium / 1.) THF, hexane, -78 deg C 2.) THF, hexane, 0 deg C
5: 1.) n-butyllithium, HMPA / 1.)THF, hexane, -78 degC to 0 degC 2.) 45-50 degC, 2 h
With
N,N,N,N,N,N-hexamethylphosphoric triamide; n-butyllithium; sodium acetate; pyridinium chlorochromate;
toluene-4-sulfonic acid;
In
tetrahydrofuran; diethyl ether; dichloromethane;
DOI:10.1021/jo00183a018
