3-Pyridazinecarbonitrile, 1-benzoyl-5-[[(1,1-dimethylethyl)dimethylsilyl]oxy]hexahydro-, (3S,5S)-

Base Information

Chemical Name:3-Pyridazinecarbonitrile, 1-benzoyl-5-[[(1,1-dimethylethyl)dimethylsilyl]oxy]hexahydro-, (3S,5S)-
CAS No.:821806-82-0
Molecular Formula:C₁₈H₂₇N₃O₂Si
Molecular Weight:345.517
Hs Code.:

Synonyms:(3S,5S)-1-Benzoyl-5-(tert-butyl-dimethyl-silanyloxy)-hexahydro-pyridazine-3-carbonitrile;

Suppliers and Price of 3-Pyridazinecarbonitrile, 1-benzoyl-5-[[(1,1-dimethylethyl)dimethylsilyl]oxy]hexahydro-, (3S,5S)-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 3-Pyridazinecarbonitrile, 1-benzoyl-5-[[(1,1-dimethylethyl)dimethylsilyl]oxy]hexahydro-, (3S,5S)-

Chemical Property:

PSA：65.36000
LogP:3.58638

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 3-Pyridazinecarbonitrile, 1-benzoyl-5-[[(1,1-dimethylethyl)dimethylsilyl]oxy]hexahydro-, (3S,5S)-

There total 4 articles about 3-Pyridazinecarbonitrile, 1-benzoyl-5-[[(1,1-dimethylethyl)dimethylsilyl]oxy]hexahydro-, (3S,5S)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 821806-80-8
(S)-1-benzoyl-5-(tert-butyldimethylsilyloxy)-1,4,5,6-tetrahydropyridazine

: 7677-24-9
trimethylsilyl cyanide

: (3R,5S)-1-benzoyl-5-(tert-butyldimethylsilyloxy)-hexahydropyridazine-3-carbonitrile

: 821806-82-0
(3S,5S)-1-benzoyl-5-(tert-butyldimethylsilyloxy)-hexahydropyridazine-3-carbonitrile

Guidance literature:: With sodium acetate; zinc trifluoromethanesulfonate; acetic acid; at 0 - 23 ℃; for 24h;
DOI:10.1016/j.tetasy.2006.06.004

Reference yield:

: 169522-70-7
(S)-3-<(tert-butyldimethylsilyl)oxy>-4-(tosyloxy)butanal

: 821806-82-0
(3S,5S)-1-benzoyl-5-(tert-butyldimethylsilyloxy)-hexahydropyridazine-3-carbonitrile

Guidance literature:: Multi-step reaction with 3 steps

1: 93 percent / hydrazine monohydrate / ethanol / 0 - 23 °C

2: 98 percent / pyridine / 0 - 23 °C

3: magnesium acetate; acetic acid / 17 h / 0 - 23 °C

With pyridine; magnesium acetate; hydrazine hydrate; acetic acid; In ethanol; 3: Strecker synthesis;
DOI:10.1016/j.tetasy.2006.06.004

Reference yield:

: 909730-49-0
(S)-5-(tert-butyldimethylsilyloxy)-1,4,5,6-tetrahydropyridazine

: 821806-82-0
(3S,5S)-1-benzoyl-5-(tert-butyldimethylsilyloxy)-hexahydropyridazine-3-carbonitrile

Guidance literature:: Multi-step reaction with 2 steps

1: 98 percent / pyridine / 0 - 23 °C

2: magnesium acetate; acetic acid / 17 h / 0 - 23 °C

With pyridine; magnesium acetate; acetic acid; 2: Strecker synthesis;
DOI:10.1016/j.tetasy.2006.06.004