82219-47-4 Usage
Chemical structure
A synthetic organic compound with a pyridine core and two carboxylic acid groups, a nitrophenyl group, an isopropyl group, and a hydroxyethyl ester group.
Molecular weight
Approximately 415.4 g/mol
Appearance
Likely a solid, although specific appearance is not provided in the material.
Solubility
The solubility of this compound is not explicitly mentioned in the material, but it may be soluble in organic solvents such as ethanol, methanol, or dimethyl sulfoxide (DMSO) due to its organic nature.
Stability
The stability of the compound is not mentioned in the material, but it may be sensitive to light, heat, or moisture due to the presence of a nitro group and other functional groups.
Potential applications
The compound may have potential applications in pharmaceuticals due to its structure, which suggests it may have biological activity and could be used in drug development.
Further research
More research is needed to determine the specific properties, potential uses, and safety profile of this compound.
Synthesis
The synthesis of this compound is not described in the material, but it is likely synthesized through a series of chemical reactions involving the formation of the pyridine core, attachment of functional groups, and formation of the ester linkage.
Reactivity
The reactivity of this compound is not explicitly mentioned in the material, but it may be reactive towards nucleophiles, reducing agents, or other reagents that can interact with its functional groups, such as the nitro group, carboxylic acid groups, or the ester linkage.
Check Digit Verification of cas no
The CAS Registry Mumber 82219-47-4 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,2,2,1 and 9 respectively; the second part has 2 digits, 4 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 82219-47:
(7*8)+(6*2)+(5*2)+(4*1)+(3*9)+(2*4)+(1*7)=124
124 % 10 = 4
So 82219-47-4 is a valid CAS Registry Number.
82219-47-4Relevant articles and documents
Nimodipine: Synthesis and metabolic pathway
Meyer,Wehinger,Bossert,Scherling
, p. 106 - 112 (2007/10/02)
Key step of the synthesis of the calcium antagonistic cerebral vasodilator (±) isopropyl-2-methoxyethyl 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylate (Bay e 9736, nimodipine) is the cyclising Michael addition. A pharmacokinetic study with 14C-nimodipine in the rat revealed as major metabolites the dihydropyridines as well as the pyridines. A potential metabolic pathway is discussed involving ether cleavage and oxidation to the pyridine form as primary biotransformation steps. Reference metabolites were synthesized using 1,4-dihydropyridines with appropriate functionalities as precursors.
