Carbamic acid, [[3-[1-[3-(aminocarbonyl)-5-[3-(2-thienyl)-1,2,4-oxadiazol-5-yl]benzoyl]-4 -piperidinyl]-4-fluorophenyl]methyl]-, 1,1-dimethylethyl ester

Base Information

Chemical Name:Carbamic acid, [[3-[1-[3-(aminocarbonyl)-5-[3-(2-thienyl)-1,2,4-oxadiazol-5-yl]benzoyl]-4 -piperidinyl]-4-fluorophenyl]methyl]-, 1,1-dimethylethyl ester
CAS No.:823195-24-0
Molecular Formula:C31H32FN5O5S
Molecular Weight:605.69
Hs Code.:

Carbamic acid,
[[3-[1-[3-(aminocarbonyl)-5-[3-(2-thienyl)-1,2,4-oxadiazol-5-yl]benzoyl]-4
-piperidinyl]-4-fluorophenyl]methyl]-, 1,1-dimethylethyl ester

Synonyms:

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Chemical Property of Carbamic acid, [[3-[1-[3-(aminocarbonyl)-5-[3-(2-thienyl)-1,2,4-oxadiazol-5-yl]benzoyl]-4 -piperidinyl]-4-fluorophenyl]methyl]-, 1,1-dimethylethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of Carbamic acid, [[3-[1-[3-(aminocarbonyl)-5-[3-(2-thienyl)-1,2,4-oxadiazol-5-yl]benzoyl]-4 -piperidinyl]-4-fluorophenyl]methyl]-, 1,1-dimethylethyl ester

There total 3 articles about Carbamic acid, [[3-[1-[3-(aminocarbonyl)-5-[3-(2-thienyl)-1,2,4-oxadiazol-5-yl]benzoyl]-4 -piperidinyl]-4-fluorophenyl]methyl]-, 1,1-dimethylethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 823195-18-2
5-(3-thiophen-2-yl-[1,2,4]oxadiazol-5-yl)-isophthalamic acid

: 823195-19-3
tert-butyl 4-fluoro-3-(piperidin-4-yl)benzylcarbamate

: 823195-24-0
(3-{1-[3-carbamoyl-5-(3-thiophen-2-yl-[1,2,4]oxadiazol-5-yl)-benzoyl]-piperidin-4-yl}-4-fluoro-benzyl)-carbamic acid tert-butyl ester

Guidance literature:: With O-[(ethoxycarbonyl)cyanomethyleneamino]-N,N,N',N'-tetramethyluronium tetrafluoroborate; dipropylethylamine; In N,N-dimethyl-formamide; at 0 - 20 ℃;
DOI:10.1016/j.bmcl.2004.09.065

Reference yield:

: 4105-93-5
1,3-bis(ethoxycarbonyl)benzoic acid

: 823195-24-0
(3-{1-[3-carbamoyl-5-(3-thiophen-2-yl-[1,2,4]oxadiazol-5-yl)-benzoyl]-piperidin-4-yl}-4-fluoro-benzyl)-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride / toluene

1.2: 85 percent / toluene / 120 °C

2.1: aq. LiOH / dioxane / 2 h / 20 °C

2.2: NH₄Cl; TOTU; Pr₂NEt / dimethylformamide / 0 - 20 °C

2.3: 78 percent / aq. LiOH / dioxane / 2 h / 20 °C

3.1: 75 percent / TOTU; Pr₂NEt / dimethylformamide / 0 - 20 °C

With lithium hydroxide; O-[(ethoxycarbonyl)cyanomethyleneamino]-N,N,N',N'-tetramethyluronium tetrafluoroborate; dipropylethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In 1,4-dioxane; N,N-dimethyl-formamide; toluene;
DOI:10.1016/j.bmcl.2004.09.065

Reference yield:

: 823195-13-7
5-(3-thiophen-2-yl-[1,2,4]oxadiazol-5-yl)-isophthalic acid diethyl ester

: 823195-24-0
(3-{1-[3-carbamoyl-5-(3-thiophen-2-yl-[1,2,4]oxadiazol-5-yl)-benzoyl]-piperidin-4-yl}-4-fluoro-benzyl)-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: aq. LiOH / dioxane / 2 h / 20 °C

1.2: NH₄Cl; TOTU; Pr₂NEt / dimethylformamide / 0 - 20 °C

1.3: 78 percent / aq. LiOH / dioxane / 2 h / 20 °C

2.1: 75 percent / TOTU; Pr₂NEt / dimethylformamide / 0 - 20 °C

With lithium hydroxide; O-[(ethoxycarbonyl)cyanomethyleneamino]-N,N,N',N'-tetramethyluronium tetrafluoroborate; dipropylethylamine; In 1,4-dioxane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2004.09.065