1-(((9h-Fluoren-9-yl)methoxy)carbonyl)-4-(tert-butoxycarbonyl)piperazine-2-carboxylic acid

Base Information

• Chemical Name: 1-(((9h-Fluoren-9-yl)methoxy)carbonyl)-4-(tert-butoxycarbonyl)piperazine-2-carboxylic acid
• CAS No.: 183742-23-6
• Molecular Formula: C25H28N2O6
• Molecular Weight: 452.507
• Hs Code.: 2933599590
• European Community (EC) Number: 672-408-2
• DSSTox Substance ID: DTXSID60373545
• Mol file: 183742-23-6.mol

Synonyms:183742-23-6;4-boc-1-fmoc-2-piperazinecarboxylic acid;N-4-Boc-N-1-Fmoc-2-piperazine carboxylic acid;1-(((9h-fluoren-9-yl)methoxy)carbonyl)-4-(tert-butoxycarbonyl)piperazine-2-carboxylic acid;1-(9H-fluoren-9-ylmethoxycarbonyl)-4-[(2-methylpropan-2-yl)oxycarbonyl]piperazine-2-carboxylic acid;1-Fmoc-4-Boc-piperazine-2-carboxylic acid;4-(tert-butoxycarbonyl)-1-[(9h-fluoren-9-ylmethoxy)carbonyl]-2-piperazinecarboxylic acid;4-[(tert-butoxy)carbonyl]-1-[(9H-fluoren-9-ylmethoxy)carbonyl]piperazine-2-carboxylic acid;4-[(TERT-BUTOXY)CARBONYL]-1-{[(9H-FLUOREN-9-YL)METHOXY]CARBONYL}PIPERAZINE-2-CARBOXYLIC ACID;(R)-1-Fmoc-4-Boc-piperazine-2-carboxylic acid;1-n-fmoc-4-n-boc-piperazine-2-carboxylic acid;SCHEMBL5190569;DTXSID60373545;2-piperazinecarboxylic acid, n1-fmoc protected, n4-boc protected;MFCD01076311;AKOS015841575;AB08222;AC-6555;SB44464;AS-18178;PIPERAZINE-1,2,4-TRICARBOXYLIC ACID 4-TERT-BUTYL ESTER 1-(9H-FLUOREN-9-YLMETHYL) ESTER;4-boc-1-fmoc-piperazine-2-carboxylic acid;A4066;CS-0089873;FT-0643759;n-4-boc-n-1-fmoc-2-piperazinecarboxylic acid;EN300-1090775;Q-102279;1-fmoc-4-(tert-butoxycarbonyl)piperazine-2-carboxylic acid;1-(((9H-fluoren-9-yl)methoxy)carbonyl)-4-(tert-butoxycarbonyl)piperazine-2-carboxylicacid;4-(tert-Butoxycarbonyl)-1-{[(9H-fluoren-9-yl)methoxy]carbonyl}piperazine-2-carboxylic acid;(+/-)-Piperazine-1,2,4-tricarboxylic acid 4-tert-butyl ester 1-(9H-fluoren-9-ylmethyl) ester;(S)-1-(((9H-Fluoren-9-yl)methoxy)carbonyl)-4-(tert-butoxycarbonyl)piperazine-2-carboxylic acid;(2S)-1-(9H-fluoren-9-ylmethoxycarbonyl)-4-[(2-methylpropan-2-yl)oxycarbonyl]piperazine-2-carboxylic acid;(S)-1-[((9H-Fluoren-9-yl)methoxy)carbonyl)-4-(tert-butoxycarbonyl)piperazine-2-carboxylic acid;(S)-4-Boc-1-Fmoc-2-piperazinecarboxylic acid;1-(((9H-fluoren-9-yl)methoxy)carbonyl)-4-(tert-butoxycarbonyl)piperazine-2-carboxylic acid;4-(tert-Butoxycarbonyl)-1-[(9H-fluoren-9-ylmethoxy)carbonyl]-2-piperazinecarboxylic acid

Chemical Property of 1-(((9h-Fluoren-9-yl)methoxy)carbonyl)-4-(tert-butoxycarbonyl)piperazine-2-carboxylic acid

Chemical Property:

• Vapor Pressure: 1.88E-16mmHg at 25°C
• Melting Point: 163 °C
• Boiling Point: 624.4 °C at 760 mmHg
• PKA: 3?+-.0.20(Predicted)
• Flash Point: 331.4 °C
• PSA: 96.38000
• Density: 1.292 g/cm³
• LogP: 3.81720
• Storage Temp.: 2-8°C
• XLogP3: 3.5
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 6
• Rotatable Bond Count: 6
• Exact Mass: 452.19473662
• Heavy Atom Count: 33
• Complexity: 728

Purity/Quality:

97% ^*data from raw suppliers

N-4-BOC-N-1-FMOC-2-PIPERAZINECARBOXYLICACID ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn, Xi
• Hazard Codes: Xi,Xn
• Statements: 20/21/22-36/37/38
• Safety Statements: 22-26-36/37/39

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(C)(C)OC(=O)N1CCN(C(C1)C(=O)O)C(=O)OCC2C3=CC=CC=C3C4=CC=CC=C24

Technology Process of 1-(((9h-Fluoren-9-yl)methoxy)carbonyl)-4-(tert-butoxycarbonyl)piperazine-2-carboxylic acid

There total 4 articles about 1-(((9h-Fluoren-9-yl)methoxy)carbonyl)-4-(tert-butoxycarbonyl)piperazine-2-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-(tert-Butoxycarbonyloxyimino)-2-phenylacetonitrile (58632-95-4) + (fluorenylmethoxy)carbonyl chloride (28920-43-6) + piperazine-2-carboxylic acid dihydrochloride (3022-15-9,126330-90-3,133525-05-0,135841-26-8) → 1-(((9H-fluoren-9-yl)methoxy)carbonyl)-4-(tert-butoxycarbonyl)piperazine-2-carboxylic acid (183742-23-6)

Guidance literature:

2-(tert-Butoxycarbonyloxyimino)-2-phenylacetonitrile; piperazine-2-carboxylic acid dihydrochloride; With sodium hydroxide; In 1,4-dioxane; water; at 20 ℃; for 5h; pH=11;

(fluorenylmethoxy)carbonyl chloride; With sodium hydroxide; In 1,4-dioxane; water; at 0 - 20 ℃; for 20h; pH=9.5;

Reference yield:

piperazine-2-carboxylic acid dihydrochloride (3022-15-9,126330-90-3,133525-05-0,135841-26-8) + 2-(tert-butoxycarbonyloxyimino)-2-phenylacetonitrile (74651-77-7) → 1-(((9H-fluoren-9-yl)methoxy)carbonyl)-4-(tert-butoxycarbonyl)piperazine-2-carboxylic acid (183742-23-6)

Guidance literature:

In 1,4-dioxane; sodium hydroxide; (+/-)-2-Carboxymethyl-piperazine-1,4-dicarboxylic acid 4-tert-butyl ester 1-(9H-fluoren-9-ylmethyl) ester; water;

Reference yield:

(fluorenylmethoxy)carbonyl chloride (28920-43-6) + piperazine-1,3-dicarboxylic acid 1-tert-butyl ester (128019-59-0) → 1-(((9H-fluoren-9-yl)methoxy)carbonyl)-4-(tert-butoxycarbonyl)piperazine-2-carboxylic acid (183742-23-6)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; water; at 0 - 20 ℃;

upstream raw materials:

(fluorenylmethoxy)carbonyl chloride

piperazine-1,3-dicarboxylic acid 1-tert-butyl ester

piperazine-2-carboxylic acid dihydrochloride

2-(tert-butoxycarbonyloxyimino)-2-phenylacetonitrile