Cytidine, 5-(azidomethyl)-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-deoxy-3'-O- [(1,1-dimethylethyl)dimethylsilyl]-

Base Information

Chemical Name:Cytidine, 5-(azidomethyl)-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-deoxy-3'-O- [(1,1-dimethylethyl)dimethylsilyl]-
CAS No.:823791-02-2
Molecular Formula:C37H46N6O6Si
Molecular Weight:698.88300
Hs Code.:

Synonyms:4-Amino-5-azidomethyl-1-[(2R,4S,5R)-5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(tert-butyl-dimethyl-silanyloxy)-tetrahydro-furan-2-yl]-1H-pyrimidin-2-one;

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Cytidine, 5-(azidomethyl)-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-deoxy-3'-O- [(1,1-dimethylethyl)dimethylsilyl]-

Chemical Property:

PSA：156.81000
LogP:7.37356

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of Cytidine, 5-(azidomethyl)-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-deoxy-3'-O- [(1,1-dimethylethyl)dimethylsilyl]-

There total 5 articles about Cytidine, 5-(azidomethyl)-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-deoxy-3'-O- [(1,1-dimethylethyl)dimethylsilyl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2,4,6-Triisopropyl-benzenesulfonic acid 5-azidomethyl-1-[(2R,4S,5R)-5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(tert-butyl-dimethyl-silanyloxy)-tetrahydro-furan-2-yl]-2-oxo-1,2-dihydro-pyrimidin-4-yl ester

: 823791-02-2
3'-O-(tert-butyl(dimethyl)silyl)-5'-O-(4,4'-dimethoxytrityl)-5-(azidomethyl)deoxycytidine

Guidance literature:: With ammonia; In 1,4-dioxane; at 20 ℃; for 6h;
DOI:10.1021/ol053125n

Reference yield:

: 137552-29-5
5-(azidomethyl)-5′-O-(4,4′-dimethoxytrityl)-2′-deoxyuridine

: 823791-02-2
3'-O-(tert-butyl(dimethyl)silyl)-5'-O-(4,4'-dimethoxytrityl)-5-(azidomethyl)deoxycytidine

Guidance literature:: Multi-step reaction with 3 steps

1: 1.02 g / imidazole / dimethylformamide / 2 h / 20 °C

2: Na₂CO₃; nBu₄NBr / CH₂Cl₂; H₂O / 2 h / 20 °C

3: 1.34 g / NH₃ gas / dioxane / 6 h / 20 °C

With 1H-imidazole; tetrabutylammomium bromide; ammonia; sodium carbonate; In 1,4-dioxane; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1021/ol053125n

Reference yield:

: 823791-01-1
3'-O-(tert-butyl(dimethyl)silyl)-5'-O-(4,4'-dimethoxytrityl)-5-(azidomethyl)deoxyuridine

: 823791-02-2
3'-O-(tert-butyl(dimethyl)silyl)-5'-O-(4,4'-dimethoxytrityl)-5-(azidomethyl)deoxycytidine

Guidance literature:: Multi-step reaction with 2 steps

1: Na₂CO₃; nBu₄NBr / CH₂Cl₂; H₂O / 2 h / 20 °C

2: 1.34 g / NH₃ gas / dioxane / 6 h / 20 °C

With tetrabutylammomium bromide; ammonia; sodium carbonate; In 1,4-dioxane; dichloromethane; water;
DOI:10.1021/ol053125n