Thymidine, a-azido-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-3'-O-[(1,1-dimethyleth yl)dimethylsilyl]-

Base Information

Chemical Name:Thymidine, a-azido-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-3'-O-[(1,1-dimethyleth yl)dimethylsilyl]-
CAS No.:823791-01-1
Molecular Formula:C37H45N5O7Si
Molecular Weight:699.86800
Hs Code.:

Synonyms:5-Azidomethyl-1-[(2R,4S,5R)-5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(tert-butyl-dimethyl-silanyloxy)-tetrahydro-furan-2-yl]-1H-pyrimidine-2,4-dione;

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Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Thymidine, a-azido-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-3'-O-[(1,1-dimethyleth yl)dimethylsilyl]-

Chemical Property:

PSA：150.76000
LogP:6.50346

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of Thymidine, a-azido-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-3'-O-[(1,1-dimethyleth yl)dimethylsilyl]-

There total 3 articles about Thymidine, a-azido-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-3'-O-[(1,1-dimethyleth yl)dimethylsilyl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 137552-29-5
5-(azidomethyl)-5′-O-(4,4′-dimethoxytrityl)-2′-deoxyuridine

: 18162-48-6
tert-butyldimethylsilyl chloride

: 823791-01-1
3'-O-(tert-butyl(dimethyl)silyl)-5'-O-(4,4'-dimethoxytrityl)-5-(azidomethyl)deoxyuridine

Guidance literature:: With 1H-imidazole; In N,N-dimethyl-formamide; at 20 ℃; for 2h;
DOI:10.1021/ol053125n

Reference yield:

: 40615-36-9
4,4'-dimethoxytrityl chloride

: 823791-01-1
3'-O-(tert-butyl(dimethyl)silyl)-5'-O-(4,4'-dimethoxytrityl)-5-(azidomethyl)deoxyuridine

Guidance literature:: Multi-step reaction with 2 steps

1: pyridine / 2 h / 20 °C

2: 1.02 g / imidazole / dimethylformamide / 2 h / 20 °C

With pyridine; 1H-imidazole; In N,N-dimethyl-formamide;
DOI:10.1021/ol053125n

Reference yield:

: 59090-48-1
5-(azidomethyl)-1-((2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)-tetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione

: 823791-01-1
3'-O-(tert-butyl(dimethyl)silyl)-5'-O-(4,4'-dimethoxytrityl)-5-(azidomethyl)deoxyuridine

Guidance literature:: Multi-step reaction with 2 steps

1: pyridine / 2 h / 20 °C

2: 1.02 g / imidazole / dimethylformamide / 2 h / 20 °C

With pyridine; 1H-imidazole; In N,N-dimethyl-formamide;
DOI:10.1021/ol053125n