Acetamide, N-[(1R,2R)-2-(4-morpholinyl)cyclohexyl]-

Base Information

Chemical Name:Acetamide, N-[(1R,2R)-2-(4-morpholinyl)cyclohexyl]-
CAS No.:824938-92-3
Molecular Formula:C₁₂H₂₂N₂O₂
Molecular Weight:226.319
Hs Code.:
DSSTox Substance ID:DTXSID70478752
Wikidata:Q82312327

Synonyms:824938-92-3;Acetamide, N-[(1R,2R)-2-(4-morpholinyl)cyclohexyl]-;DTXSID70478752

Suppliers and Price of Acetamide, N-[(1R,2R)-2-(4-morpholinyl)cyclohexyl]-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemical Property of Acetamide, N-[(1R,2R)-2-(4-morpholinyl)cyclohexyl]-

Chemical Property:

XLogP3:0.5
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:2
Exact Mass:226.168127949
Heavy Atom Count:16
Complexity:239

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(=O)NC1CCCCC1N2CCOCC2
Isomeric SMILES:CC(=O)N[C@@H]1CCCC[C@H]1N2CCOCC2

Technology Process of Acetamide, N-[(1R,2R)-2-(4-morpholinyl)cyclohexyl]-

There total 4 articles about Acetamide, N-[(1R,2R)-2-(4-morpholinyl)cyclohexyl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

: 141-78-6
ethyl acetate

: 501-53-1,94274-21-2
benzyl chloroformate

: 65430-31-1,291776-02-8
(+/-)-trans-2-(morpholin-4-yl)cyclohexanamine

: 824938-92-3
(1R,2R)-N-[2-(morpholin-4-yl)cyclohexyl]acetamide

: (1S,2S)-N-[2-(morpholin-4-yl)cyclohexyl]acetamide

: benzyl (1S,2S)-N-[2-(morpholin-4-yl)cyclohexyl]carbamate

Guidance literature:: ethyl acetate; (+/-)-trans-2-(morpholin-4-yl)cyclohexanamine; With Candida antarctica lipase B; at 28 ℃; for 8h;

benzyl chloroformate; at 0 ℃; for 15h; Title compound not separated from byproducts;
DOI:10.1002/chem.200400607

Reference yield:

: 286-20-4
cyclohexane-1,2-epoxide

: 824938-92-3
(1R,2R)-N-[2-(morpholin-4-yl)cyclohexyl]acetamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: ethanol / 18 h / Heating

2.1: MsCl; Et₃N / diethyl ether / 0 - 20 °C

2.2: aq. NH₃ / diethyl ether / 16 h / 20 °C

3.1: Candida antarctica lipase B / 8 h / 28 °C

With Candida antarctica lipase B; methanesulfonyl chloride; triethylamine; In diethyl ether; ethanol;
DOI:10.1002/chem.200400607

Reference yield:

: 14909-79-6
trans-2-morpholinocyclohexanol

: 824938-92-3
(1R,2R)-N-[2-(morpholin-4-yl)cyclohexyl]acetamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: MsCl; Et₃N / diethyl ether / 0 - 20 °C

1.2: aq. NH₃ / diethyl ether / 16 h / 20 °C

2.1: Candida antarctica lipase B / 8 h / 28 °C

With Candida antarctica lipase B; methanesulfonyl chloride; triethylamine; In diethyl ether;
DOI:10.1002/chem.200400607