Methanone, (6-methoxy-1-naphthalenyl)(1-pentyl-1H-indol-3-yl)-

Base Information

Chemical Name:Methanone, (6-methoxy-1-naphthalenyl)(1-pentyl-1H-indol-3-yl)-
CAS No.:824961-41-3
Molecular Formula:C₂₅H₂₅NO₂
Molecular Weight:371.479
Hs Code.:
UNII:BUN2P7889F
ChEMBL ID:CHEMBL563929
DSSTox Substance ID:DTXSID70463926
Wikidata:Q82289028
Mol file:824961-41-3.mol

Synonyms:824961-41-3;JWH 081 6-methoxynaphthyl isomer;Methanone, (6-methoxy-1-naphthalenyl)(1-pentyl-1H-indol-3-yl)-;(6-methoxynaphthalen-1-yl)-(1-pentylindol-3-yl)methanone;JWH-166;BUN2P7889F;UNII-BUN2P7889F;CHEMBL563929;(6-Methoxy-1-naphthalenyl)(1-pentyl-1H-indol-3-yl)methanone;JWH-081 6-Methoxynaphthyl;SCHEMBL6325916;DTXSID70463926;JWH 166;JCOOBICVPDFZNX-UHFFFAOYSA-N;BDBM50414054;1-pentyl-3-(6-methoxy-1-naphthoyl)indole;NS00067988;(6-Methoxy-1-naphthalenyl)(1-pentyl-1H-indol-3-yl)-methanone

Suppliers and Price of Methanone, (6-methoxy-1-naphthalenyl)(1-pentyl-1H-indol-3-yl)-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
JWH166
100mg
$ 1320.00

Medical Isotopes, Inc.
JWH166
100 mg
$ 2200.00

Cayman Chemical
JWH 081 6-methoxynaphthyl isomer ≥98%
10mg
$ 424.00

Cayman Chemical
JWH 081 6-methoxynaphthyl isomer ≥98%
5mg
$ 240.00

Cayman Chemical
JWH 081 6-methoxynaphthyl isomer ≥98%
1mg
$ 54.00

AK Scientific
Methanone,(6-methoxy-1-naphthalenyl)(1-pentyl-1H-indol-3-yl)-
10mg
$ 629.00

Total 6 raw suppliers

Chemical Property of Methanone, (6-methoxy-1-naphthalenyl)(1-pentyl-1H-indol-3-yl)-

Chemical Property:

Boiling Point:562.8±25.0 °C(Predicted)
PSA：31.23000
Density:1.11±0.1 g/cm3(Predicted)
LogP:6.22430
XLogP3:6.3
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:7
Exact Mass:371.188529040
Heavy Atom Count:28
Complexity:521

Purity/Quality:

99% ^*data from raw suppliers

JWH166 ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCCCCN1C=C(C2=CC=CC=C21)C(=O)C3=CC=CC4=C3C=CC(=C4)OC
Uses JWH 166 is a potent and highly selective CB2 agonist.

Technology Process of Methanone, (6-methoxy-1-naphthalenyl)(1-pentyl-1H-indol-3-yl)-

There total 4 articles about Methanone, (6-methoxy-1-naphthalenyl)(1-pentyl-1H-indol-3-yl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 59529-21-4
1-pentyl-1H-indole

: 36112-61-5
6-methoxy-1-naphthoic acid

: 824961-41-3
(6-methoxy-1-naphthalenyl)(1-pentyl-1H-indol-3-yl)methanone

Guidance literature:: 6-methoxy-1-naphthoic acid; With oxalyl dichloride; In dichloromethane; for 1h; Heating;

1-pentyl-1H-indole; With ethylaluminum dichloride; In toluene; for 18h;
DOI:10.1016/j.bmc.2004.09.050

Reference yield: 81.0%

: 824961-41-3
(6-methoxy-1-naphthalenyl)(1-pentyl-1H-indol-3-yl)methanone

Guidance literature:

Reference yield:

: 22604-07-5
6-methoxy-1-naphthol

: 824961-41-3
(6-methoxy-1-naphthalenyl)(1-pentyl-1H-indol-3-yl)methanone

Guidance literature:: Multi-step reaction with 3 steps

1.1: 84 percent / pyridine / 18 h / 20 °C

2.1: 65 percent / 1,3-bis(diphenylphosphino)propane; triethylamine; formic acid / Pd(OAc)2 / dimethylformamide / 6 h / 20 °C

3.1: oxalyl chloride / CH₂Cl₂ / 1 h / Heating

3.2: 81 percent / EtAlCl₂ / toluene / 18 h

With pyridine; formic acid; oxalyl dichloride; 1,3-bis-(diphenylphosphino)propane; triethylamine; palladium diacetate; In dichloromethane; N,N-dimethyl-formamide; 3.2: Friedel-Crafts reaction;
DOI:10.1016/j.bmc.2004.09.050