36112-61-5

Basic information

• Product Name: 6-METHOXY-1-NAPHTHOIC ACID
• Synonyms: 6-METHOXY-1-NAPHTHOIC ACID;6-METHOXY-1-NAPHTHOIC ACID 6-;Methoxy naphthoic acid;6-methoxy-1-naphthalenecarboxylic acid
• CAS NO: 36112-61-5
• Molecular Formula: C₁₂H₁₀O₃
• Molecular Weight: 202.21
• Mol File: 36112-61-5.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 403.3 °C at 760 mmHg
• Flash Point: 162.3 °C
• Appearance: /
• Density: 1.263 g/cm³
• Vapor Pressure: 3.14E-07mmHg at 25°C
• Refractive Index: 1.64
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 6-METHOXY-1-NAPHTHOIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 6-METHOXY-1-NAPHTHOIC ACID(36112-61-5)
• EPA Substance Registry System: 6-METHOXY-1-NAPHTHOIC ACID(36112-61-5)

Safety Data

• Hazardous Substances Data: 36112-61-5(Hazardous Substances Data)

Usage

General Description

6-Methoxy-1-naphthoic acid is a chemical compound with the molecular formula C12H10O3. It is a derivative of naphthalene and belongs to the class of organic compounds known as methoxyphenols. This chemical is used in the synthesis of various pharmaceuticals and organic compounds due to its aromatic and acidic properties. It exhibits anti-inflammatory and analgesic effects and has been studied for its potential therapeutic applications. Additionally, 6-methoxy-1-naphthoic acid is also used in the manufacture of dyes and pigments due to its characteristic color properties.

InChI:InChI=1/C12H10O3/c1-15-9-5-6-10-8(7-9)3-2-4-11(10)12(13)14/h2-7H,1H3,(H,13,14)

Upstream product

• 5289-78-1 3-methoxy-1,8-naphthalic anhydride 
• 69769-74-0 4,6-dimethoxy-1-naphthylbenzyl ketone 
• 6132-93-0 β-(4,6-dimethoxy-1-naphthoyl)propionic acid 
• 42200-95-3 4,6-dimethoxy-1-naphthylmethyl ketone 

Downstream Products

• 880252-18-6 3-methoxy-11H-benzo[a]fluoren-11-one 
• 1338220-70-4 N-[3-benzyl-5-(4-hydroxyphenyl)pyrazin-2-yl]-6-hydroxy-1-naphthamide 
• 1338221-34-3 N-[3-benzyl-5-(4-methoxyphenyl)pyrazin-2-yl]-6-methoxy-N-(6-methoxy-1-naphthoyl)-1-naphthamide 
• 80859-00-3 6-hydroxy-1,2,3,4-tetrahydro-[1]naphthoic acid 
• 77029-02-8 2-(6-methoxy-1-naphthyl)-1-phenyl-2-propanol 
• 82214-72-0 Ethyl 3-(6-methoxy-1-naphthylmethyl)-2-methyl-4-oxo-cyclohexane carboxylate 
• 82214-71-9 Ethyl 3-(6-methoxy-1-naphthylmethyl)-2-methyl-4-oxo-cyclohex-2-enecarboxylate 
• 824961-41-3 (6-methoxy-1-naphthalenyl)(1-pentyl-1H-indol-3-yl)methanone 
• 83379-75-3 benzyl (6-methoxynaphthyl)carbamate 
• 58149-89-6 1-(6-methoxynaphthalen-1-yl)ethanone 
• 2437-17-4 6-hydroxy-1-naphthoic acid 
• 80858-95-3 6-methoxy-1,2,3,4-tetrahydronaphthalene-1-carboxylic acid 
• 61109-48-6 6-methoxy-1-naphthalenecarboxylic acid methyl ester 

Relevant articles and documents

The mercury-mediated decarboxylation (Pesci reaction) of naphthoic anhydrides investigated by microwave synthesis

The mercury-mediated decarboxylation (Pesci reaction) of several substituted naphthoic anhydrides has been investigated by microwave synthesis. A laboratory microwave reactor was found to be ideal for small-scale preparations of this slow reaction, reducing reaction times from typically four days to less than 1 h for the three-step process. The ionic reaction medium rapidly heated to high temperatures under microwave heating and could be efficiently maintained by low microwave power settings. Generation of stoichiometric CO2 was safely contained within the reaction tubes. A simplified reaction procedure has been developed. For substituted naphthoic anhydrides, 1H NMR analysis of the naphthoate ester derivatives indicated no change in the regioisomer ratio compared to previously reported thermal values.

Efficient syntheses of some 1-naphthylalkyl ketones and studies on their autooxidation in basic medium

Birch reductions of 4,6-dimethoxy-1-naphthylalkyl ketones 1 provided in fair to good yields the demethoxylated products, 6-methoxy-1-naphthylalkyl ketones 2(a-g), not easily accessible by other procedures. Autooxidation of these ketones in basic medium afforded the diketones 6(a-c), the acid 2h, and interestingly the phenol 5. Extension of this reduction to the related tricyclic ketone 8 afforded 9a, the phenolic ketone 9b; and significantly the dihydrocoumarin derivative 10 as a result of autooxidation of 9a. The mechanisms for demethoxylation and autooxidation have been discussed.