1-Azetidineacetic acid, 3-[(1S)-1-[[(2S)-2-[[(9H-fluoren-9-ylmethoxy)carbonyl]amino]-1-oxoprop yl]amino]-3-methylbutyl]-2-oxo-4-phenyl-, methyl ester, (3R,4S)-

Base Information

Chemical Name:1-Azetidineacetic acid, 3-[(1S)-1-[[(2S)-2-[[(9H-fluoren-9-ylmethoxy)carbonyl]amino]-1-oxoprop yl]amino]-3-methylbutyl]-2-oxo-4-phenyl-, methyl ester, (3R,4S)-
CAS No.:825615-44-9
Molecular Formula:C₃₅H₃₉N₃O₆
Molecular Weight:597.711
Hs Code.:

1-Azetidineacetic acid,
3-[(1S)-1-[[(2S)-2-[[(9H-fluoren-9-ylmethoxy)carbonyl]amino]-1-oxoprop
yl]amino]-3-methylbutyl]-2-oxo-4-phenyl-, methyl ester, (3R,4S)-

Synonyms:

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Chemical Property of 1-Azetidineacetic acid, 3-[(1S)-1-[[(2S)-2-[[(9H-fluoren-9-ylmethoxy)carbonyl]amino]-1-oxoprop yl]amino]-3-methylbutyl]-2-oxo-4-phenyl-, methyl ester, (3R,4S)-

Chemical Property:

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MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 1-Azetidineacetic acid, 3-[(1S)-1-[[(2S)-2-[[(9H-fluoren-9-ylmethoxy)carbonyl]amino]-1-oxoprop yl]amino]-3-methylbutyl]-2-oxo-4-phenyl-, methyl ester, (3R,4S)-

There total 4 articles about 1-Azetidineacetic acid, 3-[(1S)-1-[[(2S)-2-[[(9H-fluoren-9-ylmethoxy)carbonyl]amino]-1-oxoprop yl]amino]-3-methylbutyl]-2-oxo-4-phenyl-, methyl ester, (3R,4S)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 86060-86-8
(9H-fluoren-9-yl-methoxy)carbonyl-L-alanine pentafluorophenyl ester

: [(3R,4S)-3-((S)-1-Amino-3-methyl-butyl)-2-oxo-4-phenyl-azetidin-1-yl]-acetic acid methyl ester

: 825615-44-9
((3R,4S)-3-{(S)-1-[(S)-2-(9H-Fluoren-9-ylmethoxycarbonylamino)-propionylamino]-3-methyl-butyl}-2-oxo-4-phenyl-azetidin-1-yl)-acetic acid methyl ester

Guidance literature:: In tetrahydrofuran; for 2.5h;
DOI:10.1002/ejoc.200400295

Reference yield:

: 66646-88-6
methyl 2-(benzylideneamino)acetate

: 825615-44-9
((3R,4S)-3-{(S)-1-[(S)-2-(9H-Fluoren-9-ylmethoxycarbonylamino)-propionylamino]-3-methyl-butyl}-2-oxo-4-phenyl-azetidin-1-yl)-acetic acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 42 percent / diethyl ether / 1.5 h / -30 °C / UV-irradiation

2: Et₂NH / tetrahydrofuran / 5 h

3: 94 percent / tetrahydrofuran / 2.5 h

With diethylamine; In tetrahydrofuran; diethyl ether;
DOI:10.1002/ejoc.200400295

Reference yield:

: 100-52-7
benzaldehyde

: 825615-44-9
((3R,4S)-3-{(S)-1-[(S)-2-(9H-Fluoren-9-ylmethoxycarbonylamino)-propionylamino]-3-methyl-butyl}-2-oxo-4-phenyl-azetidin-1-yl)-acetic acid methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: CH₂Cl₂ / 3 h / 20 °C

2: 42 percent / diethyl ether / 1.5 h / -30 °C / UV-irradiation

3: Et₂NH / tetrahydrofuran / 5 h

4: 94 percent / tetrahydrofuran / 2.5 h

With diethylamine; In tetrahydrofuran; diethyl ether; dichloromethane;
DOI:10.1002/ejoc.200400295