N-(2-FORMYL-3-METHOXY-PHENYL)-2,2-DIMETHYL-PROPIONAMIDE

Base Information

• Chemical Name: N-(2-FORMYL-3-METHOXY-PHENYL)-2,2-DIMETHYL-PROPIONAMIDE
• CAS No.: 82673-65-2
• Molecular Formula: C13H17NO3
• Molecular Weight: 235.283
• Hs Code.: 2924299090
• Mol file: 82673-65-2.mol

Synonyms:formylmethoxyphenyldimethylpropanamide;2'-formyl-3'-methoxy-2,2-dimethylpropionanilide;2-formyl-3-methoxy-N-pivaloylaniline;

Chemical Property of N-(2-FORMYL-3-METHOXY-PHENYL)-2,2-DIMETHYL-PROPIONAMIDE

Chemical Property:

• Melting Point: 82-84oC
• PSA: 55.40000
• LogP: 2.56530

Purity/Quality:

N-(2-Formyl-3-methoxyphenyl)-2,2-dimethylpropanamide >95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-(2-FORMYL-3-METHOXY-PHENYL)-2,2-DIMETHYL-PROPIONAMIDE

There total 3 articles about N-(2-FORMYL-3-METHOXY-PHENYL)-2,2-DIMETHYL-PROPIONAMIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

N,N-dimethyl-formamide (68-12-2,33513-42-7) → N-(2-formyl-3-methoxyphenyl)pivalamide (82673-65-2)

Guidance literature:

N-(3-methoxyphenyl)pivalamide; With n-butyllithium; In tetrahydrofuran; at 0 ℃; for 1h;

N,N-dimethyl-formamide; In tetrahydrofuran; at 0 - 20 ℃;

With ammonium chloride; In tetrahydrofuran; water;

Reference yield:

N-(3-methoxyphenyl)pivalamide (56619-93-3) + N,N-dimethyl-formamide (68-12-2,33513-42-7) → N-(2-formyl-3-methoxyphenyl)pivalamide (82673-65-2)

Guidance literature:

With sec.-butyllithium; In tetrahydrofuran; hexane; 1.) 0 deg C, 2 h, 2.) 0 deg C, 1 h; r.t., 12 h;

DOI:10.1055/s-1998-2119

Reference yield:

pivaloyl chloride (3282-30-2) + m-Anisidine (536-90-3,918666-97-4) → N-(2-formyl-3-methoxyphenyl)pivalamide (82673-65-2)

Guidance literature:

With n-butyllithium; triethylamine; Yield given. Multistep reaction; 1.) hexane, tetrahydrofuran, 0 deg C, 2 h; 2.) dimethylformamide, 0 deg C, 1 h; room temp., 8 h;

upstream raw materials:

pivaloyl chloride

m-Anisidine

N-(3-methoxyphenyl)pivalamide

N,N-dimethyl-formamide

Downstream raw materials:

5-methoxyquinoline

3-Methyl-5-methoxyquinoline

N-{2-[Bis-(1H-pyrrol-2-yl)-methyl]-3-methoxy-phenyl}-2,2-dimethyl-propionamide

5-methoxy-2(1H)-quinolinone