(4-((2,5-Dioxopyrrolidin-1-yloxy)carbonyl)phenyl)(thiophen-2-yl)iodonium trifluoroacetate

Base Information

• Chemical Name: (4-((2,5-Dioxopyrrolidin-1-yloxy)carbonyl)phenyl)(thiophen-2-yl)iodonium trifluoroacetate
• CAS No.: 1196658-43-1
• Molecular Formula: C₂F₃O₂*C₁₅H₁₁INO₄S
• Molecular Weight: 541.243
• Mol file: 1196658-43-1.mol

Synonyms:(4-((2,5-Dioxopyrrolidin-1-yloxy)carbonyl)phenyl)(thiophen-2-yl)iodonium trifluoroacetate

Chemical Property of (4-((2,5-Dioxopyrrolidin-1-yloxy)carbonyl)phenyl)(thiophen-2-yl)iodonium trifluoroacetate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (4-((2,5-Dioxopyrrolidin-1-yloxy)carbonyl)phenyl)(thiophen-2-yl)iodonium trifluoroacetate

There total 1 articles about (4-((2,5-Dioxopyrrolidin-1-yloxy)carbonyl)phenyl)(thiophen-2-yl)iodonium trifluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 26.0%

diacetoxyiodo-2-thiophene + 4-(tributylstannyl)benzoic acid N-hydroxyl succinimidyl ester (107759-58-0) → (4-((2,5-Dioxopyrrolidin-1-yloxy)carbonyl)phenyl)(thiophen-2-yl)iodonium trifluoroacetate (1196658-43-1)

Guidance literature:

diacetoxyiodo-2-thiophene; With trifluoroacetic acid; In dichloromethane; at -30 - 20 ℃; Inert atmosphere;

4-(tributylstannyl)benzoic acid N-hydroxyl succinimidyl ester; In dichloromethane; at -30 - 20 ℃; Inert atmosphere;

Reference yield: 23.0%

(4-((2,5-Dioxopyrrolidin-1-yloxy)carbonyl)phenyl)(thiophen-2-yl)iodonium trifluoroacetate (1196658-43-1) → N-succinimidyl 4-[18F]fluorobenzoate (141762-27-8)

Guidance literature:

With 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; potassium carbonate; [2.2.2]cryptande; In N,N-dimethyl-formamide; at 130 ℃; for 0.0833333h; Inert atmosphere;

Reference yield: 10.0%

(4-((2,5-Dioxopyrrolidin-1-yloxy)carbonyl)phenyl)(thiophen-2-yl)iodonium trifluoroacetate (1196658-43-1) → p-fluorobenzoic acid succinimidyl ester (66134-67-6)

Guidance literature:

With 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; 3-(trifluoromethyl)anisole; cesium fluoride; In N,N-dimethyl-formamide; at 110 ℃; Product distribution / selectivity; Inert atmosphere;

upstream raw materials:

4-(tributylstannyl)benzoic acid N-hydroxyl succinimidyl ester

Downstream raw materials:

p-fluorobenzoic acid succinimidyl ester

N-succinimidyl 4-[18F]fluorobenzoate