Technology Process of 4-Nonenoic acid,
7-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-9-[(4-methoxyphenyl)methoxy]-4,
6,8-trimethyl-, (1,1-dimethylethyl)dimethylsilyl ester, (4Z,6S,7R,8S)-
There total 11 articles about 4-Nonenoic acid,
7-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-9-[(4-methoxyphenyl)methoxy]-4,
6,8-trimethyl-, (1,1-dimethylethyl)dimethylsilyl ester, (4Z,6S,7R,8S)- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: CBr4; PPh3
2.1: LiHMDS / tetrahydrofuran
2.2: 98 percent / tetrahydrofuran
3.1: 87 percent / 2,6-lutidine
With
2,6-dimethylpyridine; carbon tetrabromide; triphenylphosphine; lithium hexamethyldisilazane;
In
tetrahydrofuran;
DOI:10.1021/jo048534w
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: dicyclohexylboron chloride; triethylamine / diethyl ether
1.2: LiBH4 / diethyl ether
2.1: TEMPO; bis-acetoxyiodobenzene / CH2Cl2 / 3 h / 20 °C
3.1: KHMDS; 18-crown-6 / tetrahydrofuran; toluene / 0.5 h / -78 °C
3.2: tetrahydrofuran; toluene / 0.67 h
4.1: 1.64 g / 2,6-lutidine / CH2Cl2 / 4 h / -78 °C
5.1: 90 percent / DIBAL-H / CH2Cl2; hexane / 1 h / -78 °C
6.1: CBr4; PPh3
7.1: LiHMDS / tetrahydrofuran
7.2: 98 percent / tetrahydrofuran
8.1: 87 percent / 2,6-lutidine
With
2,6-dimethylpyridine; 2,2,6,6-tetramethyl-piperidine-N-oxyl; 18-crown-6 ether; carbon tetrabromide; [bis(acetoxy)iodo]benzene; dicyclohexylboron chloride; potassium hexamethylsilazane; diisobutylaluminium hydride; triethylamine; triphenylphosphine; lithium hexamethyldisilazane;
In
tetrahydrofuran; diethyl ether; hexane; dichloromethane; toluene;
DOI:10.1021/jo048534w
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: 296 mg / sodium periodate; sodium bicarbonate / methanol; H2O / 0.17 h / 20 °C / pH 7
2.1: KHMDS; 18-crown-6 / tetrahydrofuran; toluene / 0.5 h / -78 °C
2.2: tetrahydrofuran; toluene / 0.67 h
3.1: 1.64 g / 2,6-lutidine / CH2Cl2 / 4 h / -78 °C
4.1: 90 percent / DIBAL-H / CH2Cl2; hexane / 1 h / -78 °C
5.1: CBr4; PPh3
6.1: LiHMDS / tetrahydrofuran
6.2: 98 percent / tetrahydrofuran
7.1: 87 percent / 2,6-lutidine
With
2,6-dimethylpyridine; sodium periodate; 18-crown-6 ether; carbon tetrabromide; potassium hexamethylsilazane; diisobutylaluminium hydride; sodium hydrogencarbonate; triphenylphosphine; lithium hexamethyldisilazane;
In
tetrahydrofuran; methanol; hexane; dichloromethane; water; toluene;
DOI:10.1021/jo048534w
