496035-35-9

Upstream product

• 50-00-0 formaldehyd 
• 182193-69-7 (S)-1-(p-methoxybenzyloxy)-2-methylpentan-3-one 

Downstream Products

• 133007-95-1 (2S,3R,4S)-5-[(4-methoxybenzyl)oxy]-2,4-dimethylpentane-1,3-diol 
• 827603-09-8 (4-methoxy-2,6-dimethylphenyl) (2S,3S,4S,5S,6S,7Z)-2-[(2Z,4S,5R,6S)-5-(t-butyldimethylsilyloxy)-7-(p-methoxybenzyloxy)-2,4,6-trimethylhept-2-enyl]-3-hydroxy-5-(p-methoxybenzyloxy)-4,6-dimethyldeca-7,9-dienoate 
• 827603-15-6 C₃₂H₅₈O₅Si₂ 
• 827603-06-5 (Z)-(6S,7R,8S)-7-(tert-Butyl-dimethyl-silanyloxy)-9-(4-methoxy-benzyloxy)-4,6,8-trimethyl-non-4-enoic acid tert-butyl ester 
• 827603-05-4 {(Z)-(1R,2S)-5-Bromo-1-[(S)-2-(4-methoxy-benzyloxy)-1-methyl-ethyl]-2,4-dimethyl-pent-3-enyloxy}-tert-butyl-dimethyl-silane 
• 649756-12-7 methyl (2R,3S,4S)-3-triethylsilyloxy-5-(4-methoxybenzyloxy)-2,4-dimethylpentanoate 
• 496035-34-8 4-methoxy-2,6-dimethylphenyl (4Z,6S,7R,8S)-7-(t-butyldimethylsilyloxy)-9-(p-methoxybenzyloxy)-4,6,8-trimethylnon-4-enoate 
• 496035-40-6 methyl (2Z,4S,5R,6S)-5-(t-butyldimethylsilyloxy)-7-(p-methoxybenzyloxy)-2,4,6-trimethylhept-2-enoate 
• 496035-41-7 tert-Butyl-{(Z)-(1R,2S)-5-iodo-1-[(S)-2-(4-methoxy-benzyloxy)-1-methyl-ethyl]-2,4-dimethyl-pent-3-enyloxy}-dimethyl-silane 
• 496035-52-0 (2Z,4S,5R,6S)-5-(t-butyldimethylsilyloxy)-7-(p-methoxybenzyloxy)-2,4,6-trimethylhept-2-en-1-ol 
• 496035-37-1 methyl (2R,3S,4S)-3-(tert-butyldimethylsilyloxy)-2,4-dimethyl-5-(4-methoxybenzyloxy)pentanoate 
• 496766-52-0 (+)-(2S,3S,4S)-1-(tert-butyldimethylsilanyloxy)-5-(4-methoxybenzyloxy)-2,4-dimethylpentan-3-ol 
• 496035-39-3 (+)-(2S,3S,4S)-5-(tert-butyldimethylsilanyloxy)-3-(4-methoxybenzyloxy)-2,4-dimethylpentan-1-ol 
• 496035-38-2 (+)-tert-butyl-{(S)-2-[(2S,4S,5S)-2-(4-methoxyphenyl)-5-methyl[1,3]dioxan-4-yl]propoxy}dimethylsilane 

Relevant academic research and scientific papers

1,6-asymmetric induction in boron-mediated aldol reactions: application to a practical total synthesis of (+)-discodermolide.

By relying solely on substrate-based stereocontrol, a practical total synthesis of the microtubule-stabilizing anticancer agent (+)-discodermolide has been realized. This exploits a novel aldol bond construction with 1,6-stereoinduction from the boron eno

A second-generation total synthesis of (+)-discodermolide: The development of a practical route using solely substrate-based stereocontrol

(Chemical Equation Presented). A novel total synthesis of the complex polyketide (+)-discodermolide, a promising anticancer agent of sponge origin, has been completed in 7.8% overall yield over 24 linear steps, with 35 steps altogether. This second-genera

SYNTHESIS OF DISCODERMOLIDE

The invention relates to a process for preparing discodermolide, for preparing intermediates for the manufacture of discodermolide and discodermolide analogues and to the intermediates obtained during the process. Wherein the process proceeds via a tetrae