Technology Process of Benzamide,
N-[(5R,6R)-5,6-dihydro-5-hydroxy-5-methyl-4H-cyclopenta[b]thien-6-yl]-
There total 10 articles about Benzamide,
N-[(5R,6R)-5,6-dihydro-5-hydroxy-5-methyl-4H-cyclopenta[b]thien-6-yl]- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: KOH; iodobenzene diacetate / methanol / 24 h / 20 °C
1.2: 65 percent / HCl / ethanol / 2.5 h / 20 °C
2.1: 98 percent / N,N-dicyclohexylcarbodiimide; DMAP / CH2Cl2 / 8 h / 20 °C
3.1: 1.98 g / CF3COOH / CHCl3 / 3.5 h / 20 °C
4.1: 98 percent / LiOH*H2O / tetrahydrofuran; H2O / 18 h / 20 °C
5.1: 93 percent / pyridine / 24 h / 20 °C
6.1: BH3*THF / tetrahydrofuran / 6 h / Heating
7.1: 88 percent / KHCO3; IPAC / H2O / 3 h / 80 °C
With
dmap; potassium hydroxide; lithium hydroxide; borane-THF; [bis(acetoxy)iodo]benzene; potassium hydrogencarbonate; dicyclohexyl-carbodiimide; trifluoroacetic acid;
In
tetrahydrofuran; pyridine; methanol; dichloromethane; chloroform; water;
DOI:10.1002/ejoc.200400351
- Guidance literature:
-
Multi-step reaction with 9 steps
1.1: 54 percent / phosphorus pentoxide; methanesulfonic acid / 0.67 h / 20 °C
2.1: 81 percent / LDA / tetrahydrofuran / 12 h / 20 °C
3.1: KOH; iodobenzene diacetate / methanol / 24 h / 20 °C
3.2: 65 percent / HCl / ethanol / 2.5 h / 20 °C
4.1: 98 percent / N,N-dicyclohexylcarbodiimide; DMAP / CH2Cl2 / 8 h / 20 °C
5.1: 1.98 g / CF3COOH / CHCl3 / 3.5 h / 20 °C
6.1: 98 percent / LiOH*H2O / tetrahydrofuran; H2O / 18 h / 20 °C
7.1: 93 percent / pyridine / 24 h / 20 °C
8.1: BH3*THF / tetrahydrofuran / 6 h / Heating
9.1: 88 percent / KHCO3; IPAC / H2O / 3 h / 80 °C
With
dmap; phosphorus pentaoxide; potassium hydroxide; lithium hydroxide; borane-THF; methanesulfonic acid; [bis(acetoxy)iodo]benzene; potassium hydrogencarbonate; dicyclohexyl-carbodiimide; trifluoroacetic acid; lithium diisopropyl amide;
In
tetrahydrofuran; pyridine; methanol; dichloromethane; chloroform; water;
DOI:10.1002/ejoc.200400351
