2,2'-[(2-Methoxyphenyl)imino]diethanol

Base Information

• Chemical Name: 2,2'-[(2-Methoxyphenyl)imino]diethanol
• CAS No.: 28005-76-7
• Molecular Formula: C11H17 N O3
• Molecular Weight: 211.261
• Hs Code.: 2922509090
• NSC Number: 49302
• DSSTox Substance ID: DTXSID40287156
• Nikkaji Number: J141.511E
• Wikidata: Q82023096
• Mol file: 28005-76-7.mol

Synonyms:2,2'-[(2-methoxyphenyl)imino]diethanol;28005-76-7;NSC 49302;NSC49302;2-[N-(2-hydroxyethyl)-2-methoxyanilino]ethanol;SCHEMBL3779042;DTXSID40287156;ADAL1045814;2-[Di(2-hydroxyethyl)amino]anisole;NSC-49302;o-[N,N-bis(hydroxyethyl)amino]anisole;2,2'-[(2-methoxyphenyl)imino]-diethanol;2-[(2-hydroxyethyl)(2-methoxyphenyl)amino]ethan-1-ol

Chemical Property of 2,2'-[(2-Methoxyphenyl)imino]diethanol

Chemical Property:

• Boiling Point: 350.8°Cat760mmHg
• PKA: 14.31±0.10(Predicted)
• Flash Point: 165.9°C
• PSA: 52.93000
• Density: 1.177g/cm³
• LogP: 0.48620
• XLogP3: 0.6
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 6
• Exact Mass: 211.12084340
• Heavy Atom Count: 15
• Complexity: 160

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC=CC=C1N(CCO)CCO

Technology Process of 2,2'-[(2-Methoxyphenyl)imino]diethanol

There total 7 articles about 2,2'-[(2-Methoxyphenyl)imino]diethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

2-methoxy-phenylamine (90-04-0) + 2-chloro-ethanol (107-07-3) → 2-[2-hydroxyethyl-(2-methoxyphenyl)amino]ethanol (28005-76-7)

Guidance literature:

With calcium carbonate; In water; at 110 ℃; for 72h;

DOI:10.1039/b922305c

Reference yield: 86.0%

oxirane (75-21-8,99932-75-9) + 2-methoxy-phenylamine (90-04-0) → 2-[2-hydroxyethyl-(2-methoxyphenyl)amino]ethanol (28005-76-7)

Guidance literature:

With acetic acid; In tetrahydrofuran; water; for 40h;

DOI:10.1016/j.ejmech.2020.112966

Reference yield: 82.0%

[(methoxycarbonylmethyl)(2-methoxyphenyl)amino]-acetic acid methyl ester (869634-78-6) → 2-[2-hydroxyethyl-(2-methoxyphenyl)amino]ethanol (28005-76-7)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; for 12h; Reflux;

upstream raw materials:

oxirane

2-methoxy-phenylamine

2-chloro-ethanol

ethyl-2-amino-(N,N-diacetate)anisole

Downstream raw materials:

2-[(2-hydroxyethyl)(2-methoxy-4-nitrophenyl)amino]ethanol

13-(2-methoxyphenyl)-1,4,7,10-tetraoxa-13-cyclopentadecane

cis-N-(2-(4-(2-methoxyphenyl)piperazin-1-yl)cyclohexyl)benzenesulfonamide

4-(6-{2-[3-methoxy-4-(1,4,7,10-tetraoxa-13-aza-cyclopentadec-13-yl)-phenyl]-ethylamino}-1,3-dioxo-1H,3H-benzo[de]isoquinolin-2-ylmethyl)-benzoic acid tert-butyl ester