3-Bromo-N-methyl-N-boc-propylamine

Base Information

• Chemical Name: 3-Bromo-N-methyl-N-boc-propylamine
• CAS No.: 828272-19-1
• Molecular Formula: C₉H₁₈BrNO₂
• Molecular Weight: 252.151
• Mol file: 828272-19-1.mol

Synonyms:3-Bromo-N-methyl-N-boc-propylamine;

Chemical Property of 3-Bromo-N-methyl-N-boc-propylamine

Chemical Property:

• Boiling Point: 268.4±19.0 °C(Predicted)
• PKA: -1.39±0.70(Predicted)
• PSA: 29.54000
• Density: 1.254±0.06 g/cm3(Predicted)
• LogP: 2.63830
• Solubility.: Chloroform, Dichloromethane, Ethyl Acetate

Purity/Quality:

98%Min ^*data from raw suppliers

3-Bromo-N-methyl-N-boc-propylamine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-Bromo-N-methyl-N-boc-propylamine

There total 4 articles about 3-Bromo-N-methyl-N-boc-propylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

tert-butyl (3-hydroxypropyl)methylcarbamate (98642-44-5) → tert-butyl (3-bromopropyl)(methyl)carbamate (828272-19-1)

Guidance literature:

With carbon tetrabromide; triphenylphosphine; In dichloromethane; at 0 ℃; for 1.5h;

Reference yield: 85.0%

di-tert-butyl dicarbonate (24424-99-5) + 3-bromopropylamine tert-butylcarbamate (83948-53-2) + methyl iodide (74-88-4) → tert-butyl (3-bromopropyl)(methyl)carbamate (828272-19-1)

Guidance literature:

di-tert-butyl dicarbonate; 3-bromopropylamine tert-butylcarbamate; With sodium hydride; In tetrahydrofuran; for 0.5h;

methyl iodide; for 24h;

Reference yield:

di-tert-butyl dicarbonate (24424-99-5) → tert-butyl (3-bromopropyl)(methyl)carbamate (828272-19-1)

Guidance literature:

Multi-step reaction with 2 steps

1: dichloromethane / 1 h / 0 - 25 °C

2: triphenylphosphine; carbon tetrabromide / dichloromethane / 0.17 h / 0 °C

With carbon tetrabromide; triphenylphosphine; In dichloromethane;

upstream raw materials:

tert-butyl (3-hydroxypropyl)methylcarbamate

di-tert-butyl dicarbonate

3-bromopropylamine tert-butylcarbamate

methyl iodide

Refernces

• 1、 -. "MACROCYCLIC DIAMINE DERIVATIVES AS ENT INHIBITORS FOR THE TREATMENT OF CANCERS, AND COMBINATION THEREOF WITH ADENOSINE RECEPTOR ANTAGONISTS". Paragraph 0486; 0511. . Retrieved 2021/10/15.
• 2、 -. "MACROCYCLIC INDOLE DERIVATIVES". Page/Page column 244. . Retrieved 2017/12/15.