METHYL 1-(4-NITROPHENYL)-4-PIPERIDINECARBOXYLATE

Base Information

• Chemical Name: METHYL 1-(4-NITROPHENYL)-4-PIPERIDINECARBOXYLATE
• CAS No.: 7595-60-0
• Molecular Formula: C13H16N2O4
• Molecular Weight: 264.281
• Hs Code.: 2933399090
• Mol file: 7595-60-0.mol

Synonyms:1-(4-nitrophenyl)-4-piperidinecarboxylate;methyl 1-(4-nitrophenyl)-4-piperidinecarboxylate;1-(4-nitrophenyl)-piperidine-4-carboxylic acid methyl ester;

Chemical Property of METHYL 1-(4-NITROPHENYL)-4-PIPERIDINECARBOXYLATE

Chemical Property:

• Vapor Pressure: 3.98E-07mmHg at 25°C
• Melting Point: 133-135°C
• Boiling Point: 415.9°Cat760mmHg
• Flash Point: 205.3°C
• PSA: 75.36000
• Density: 1.251g/cm³
• LogP: 2.57240

Purity/Quality:

98%min ^*data from raw suppliers

Methyl 1-(4-nitrophenyl)-4-piperidinecarboxylate >95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of METHYL 1-(4-NITROPHENYL)-4-PIPERIDINECARBOXYLATE

There total 1 articles about METHYL 1-(4-NITROPHENYL)-4-PIPERIDINECARBOXYLATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

isonipecotic acid methyl ester (2971-79-1) + 4-Fluoronitrobenzene (350-46-9,178603-76-4) → methyl 1-(4-nitrophenyl)piperidine-4-carboxylate (7595-60-0)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 80 ℃; for 10h;

Reference yield: 98.0%

methyl 1-(4-nitrophenyl)piperidine-4-carboxylate (7595-60-0) → methyl 1-(4-aminophenyl)piperidine-4-carboxylate (471938-27-9)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In tetrahydrofuran; methanol; at 23 ℃; for 16h; Inert atmosphere;

DOI:10.1002/chem.201700043

Reference yield: 84.0%

methyl 1-(4-nitrophenyl)piperidine-4-carboxylate (7595-60-0) → 1-(4-nitrophenyl)-4-piperidinecarbohydrazide (1445869-21-5)

Guidance literature:

With hydrazine hydrate; In ethanol; for 24h; Reflux;

upstream raw materials:

isonipecotic acid methyl ester

4-Fluoronitrobenzene

Downstream raw materials:

methyl 1-(4-aminophenyl)piperidine-4-carboxylate

5-[1-(4-[(E)-1-(5-nitro-2-furyl)methylidene]aminophenyl)-4-piperidyl]-2,3-dihydro-1,3,4-oxadiazol-2-one

3-methyl-5-[1-(4-[(E)-1-(5-nitro-2-furyl)methylidene]aminophenyl)-4-piperidyl]-2,3-dihydro-1,3,4-oxadiazol-2-one

3-ethyl-5-[1-(4-[(E)-1-(5-nitro-2-furyl)methylidene]aminophenyl)-4-piperidyl]-2,3-dihydro-1,3,4-oxadiazol-2-one

Refernces

• 1、 -. "HETEROCYCLIC COMPOUND". Paragraph 1044. . Retrieved 2015/04/15.
• 2、 -. "SUBSTITUTED PYRIDOPYRAZINES AS NOVEL SYK INHIBITORS". Paragraph 0319; 0320. . Retrieved 2014/05/08.