5-[1-(4-[(E)-1-(5-nitro-2-furyl)methylidene]aminophenyl)-4-piperidyl]-2,3-dihydro-1,3,4-oxadiazol-2-one

Base Information

• Chemical Name: 5-[1-(4-[(E)-1-(5-nitro-2-furyl)methylidene]aminophenyl)-4-piperidyl]-2,3-dihydro-1,3,4-oxadiazol-2-one
• CAS No.: 1445868-97-2
• Molecular Formula: C₁₈H₁₇N₅O₅
• Molecular Weight: 383.363
• Mol file: 1445868-97-2.mol

Synonyms:5-[1-(4-[(E)-1-(5-nitro-2-furyl)methylidene]aminophenyl)-4-piperidyl]-2,3-dihydro-1,3,4-oxadiazol-2-one

Chemical Property of 5-[1-(4-[(E)-1-(5-nitro-2-furyl)methylidene]aminophenyl)-4-piperidyl]-2,3-dihydro-1,3,4-oxadiazol-2-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-[1-(4-[(E)-1-(5-nitro-2-furyl)methylidene]aminophenyl)-4-piperidyl]-2,3-dihydro-1,3,4-oxadiazol-2-one

There total 6 articles about 5-[1-(4-[(E)-1-(5-nitro-2-furyl)methylidene]aminophenyl)-4-piperidyl]-2,3-dihydro-1,3,4-oxadiazol-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

5-nitrofurane-2-carboxaldehyde (698-63-5) + 5-[1-(4-aminophenyl)-4-piperidyl]-2,3-dihydro-1,3,4-oxadiazol-2-one (1445869-23-7) → 5-[1-(4-[(E)-1-(5-nitro-2-furyl)methylidene]aminophenyl)-4-piperidyl]-2,3-dihydro-1,3,4-oxadiazol-2-one (1445868-97-2)

Guidance literature:

With acetic acid; In methanol; at 0 ℃; for 10h;

Reference yield:

4-Fluoronitrobenzene (350-46-9,178603-76-4) → 5-[1-(4-[(E)-1-(5-nitro-2-furyl)methylidene]aminophenyl)-4-piperidyl]-2,3-dihydro-1,3,4-oxadiazol-2-one (1445868-97-2)

Guidance literature:

Multi-step reaction with 5 steps

1: potassium carbonate / N,N-dimethyl-formamide / 10 h / 80 °C

2: hydrazine hydrate / ethanol / 24 h / Reflux

3: pyridine / 2.5 h / 85 °C / Reflux

4: tin(II) chloride dihdyrate / methanol / 4 h / 65 °C / Reflux

5: acetic acid / methanol / 10 h / 0 °C

With pyridine; tin(II) chloride dihdyrate; potassium carbonate; hydrazine hydrate; acetic acid; In methanol; ethanol; N,N-dimethyl-formamide;

Reference yield:

methyl 1-(4-nitrophenyl)piperidine-4-carboxylate (7595-60-0) → 5-[1-(4-[(E)-1-(5-nitro-2-furyl)methylidene]aminophenyl)-4-piperidyl]-2,3-dihydro-1,3,4-oxadiazol-2-one (1445868-97-2)

Guidance literature:

Multi-step reaction with 4 steps

1: hydrazine hydrate / ethanol / 24 h / Reflux

2: pyridine / 2.5 h / 85 °C / Reflux

3: tin(II) chloride dihdyrate / methanol / 4 h / 65 °C / Reflux

4: acetic acid / methanol / 10 h / 0 °C

With pyridine; tin(II) chloride dihdyrate; hydrazine hydrate; acetic acid; In methanol; ethanol;

upstream raw materials:

4-Fluoronitrobenzene

isonipecotic acid methyl ester

methyl 1-(4-nitrophenyl)piperidine-4-carboxylate

1-(4-nitrophenyl)-4-piperidinecarbohydrazide

Downstream raw materials:

5-[1-(4-[(5-nitro-2-furyl)methyl]aminophenyl)-4-piperidyl]-2,3-dihydro-1,3,4-oxadiazol-2-one

5-(1-(4-(1-((5-nitro-2-furyl)methyl)ammonio)phenyl)-4-piperidyl)-2,3-dihydro-1,3,4-oxadiazol-2-one chloride