D-Tyrosine, N-[2-[[(phenylmethoxy)carbonyl]amino]ethyl]-, methyl ester

Base Information

• Chemical Name: D-Tyrosine, N-[2-[[(phenylmethoxy)carbonyl]amino]ethyl]-, methyl ester
• CAS No.: 828923-99-5
• Molecular Formula: C₂₀H₂₄N₂O₅
• Molecular Weight: 372.421
• Mol file: 828923-99-5.mol

Synonyms:

Chemical Property of D-Tyrosine, N-[2-[[(phenylmethoxy)carbonyl]amino]ethyl]-, methyl ester

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of D-Tyrosine, N-[2-[[(phenylmethoxy)carbonyl]amino]ethyl]-, methyl ester

There total 1 articles about D-Tyrosine, N-[2-[[(phenylmethoxy)carbonyl]amino]ethyl]-, methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-benzyloxycarbonylglycinal (67561-03-9) + D-tyrosine methyl ester (3410-66-0) → (R)-2-(2-Benzyloxycarbonylamino-ethylamino)-3-(4-hydroxy-phenyl)-propionic acid methyl ester (828923-99-5)

Guidance literature:

With sodium cyanoborohydride; zinc(II) chloride; In methanol; at 20 ℃; for 18h;

DOI:10.1016/j.jorganchem.2004.09.049

Reference yield:

1-ferrocenylmethanol (1273-86-5) + (R)-2-(2-Benzyloxycarbonylamino-ethylamino)-3-(4-hydroxy-phenyl)-propionic acid methyl ester (828923-99-5) → (C5H5)Fe(C5H4CH2OC6H4CH2CH(CO2CH3)NHCH2CH2NHC(O)OCH2C6H5)

Guidance literature:

With triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; under N2; tyrosine derivative and PPh3 added at room temp. to soln. of Fe complex in dry THF; cooled to 0°C; THF soln. of DEAD added slowly; stirred at room temp. for 4 d; solvent evapd.; dissolved in CH2Cl2; washed with brine; aq. phase extd. (CH2Cl2); combined org. phase dried (Na2SO4); evapd.; purified by columnchromy. (silica gel, light petroleum-AcOEt 3:7);

DOI:10.1016/j.jorganchem.2004.09.049

upstream raw materials:

N-benzyloxycarbonylglycinal

D-tyrosine methyl ester

Refernces