Benzamide, N-[2-(3,5-dichloro-2-pyridinyl)ethyl]-2-(trifluoromethyl)-

Base Information

Chemical Name:Benzamide, N-[2-(3,5-dichloro-2-pyridinyl)ethyl]-2-(trifluoromethyl)-
CAS No.:830348-02-2
Molecular Formula:C15H11Cl2F3N2O
Molecular Weight:363.166
Hs Code.:
DSSTox Substance ID:DTXSID10461784
Wikidata:Q82286200

Synonyms:Benzamide, N-[2-(3,5-dichloro-2-pyridinyl)ethyl]-2-(trifluoromethyl)-;830348-02-2;SCHEMBL727891;DTXSID10461784;YRYSUXOCBVWBLN-UHFFFAOYSA-N

Suppliers and Price of Benzamide, N-[2-(3,5-dichloro-2-pyridinyl)ethyl]-2-(trifluoromethyl)-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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price

Total 1 raw suppliers

Chemical Property of Benzamide, N-[2-(3,5-dichloro-2-pyridinyl)ethyl]-2-(trifluoromethyl)-

Chemical Property:

XLogP3:4.3
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:4
Exact Mass:362.0200529
Heavy Atom Count:23
Complexity:409

Purity/Quality:: 85.0-99.8% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC=C(C(=C1)C(=O)NCCC2=C(C=C(C=N2)Cl)Cl)C(F)(F)F

Technology Process of Benzamide, N-[2-(3,5-dichloro-2-pyridinyl)ethyl]-2-(trifluoromethyl)-

There total 3 articles about Benzamide, N-[2-(3,5-dichloro-2-pyridinyl)ethyl]-2-(trifluoromethyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 14482-51-0
3,5-dichloro-2-bromopyridine

: 1450903-41-9
2-(trifluoromethyl)-N-vinylbenzamide

: 830348-02-2
N-(2-(3,5-dichloropyridin-2-yl)ethyl)-2-(trifluoromethyl)benzamide

Guidance literature:: With Cyclohexanethiol; 10-phenyl-10H-phenothiazine; sodium formate; In water; dimethyl sulfoxide; at 23 ℃; for 16h; regioselective reaction; Irradiation; Inert atmosphere; Sealed tube; Cooling;
DOI:10.1021/jacs.9b01077

Reference yield: 41.0%

: 25753-13-3
2-(trifluoromethyl)benzoic anhydride

: 158141-35-6
2-(3,5-dichloropyridin-2-yl)acetonitrile

: 830348-02-2
N-(2-(3,5-dichloropyridin-2-yl)ethyl)-2-(trifluoromethyl)benzamide

Guidance literature:: With sodium tetrahydroborate; cobalt(II) chloride; In methanol; at -5 - 20 ℃; for 18h;

Reference yield:

: 2-trifluoromethyl-N-vinyl-N-formyl-benzamide

: 830348-02-2
N-(2-(3,5-dichloropyridin-2-yl)ethyl)-2-(trifluoromethyl)benzamide

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hydroxide / water; tetrahydrofuran / 0 - 20 °C

2: sodium formate; 10-phenyl-10H-phenothiazine; Cyclohexanethiol / dimethyl sulfoxide; water / 16 h / 23 °C / Irradiation; Inert atmosphere; Sealed tube; Cooling

With Cyclohexanethiol; 10-phenyl-10H-phenothiazine; sodium formate; sodium hydroxide; In tetrahydrofuran; water; dimethyl sulfoxide;
DOI:10.1021/jacs.9b01077