14482-51-0

Basic information

• Product Name: 2-Bromo-3,5-dichloropyridine
• Synonyms: 2-BROMO-3,5-DICHLOROPYRIDINE;3,5-DICHLOROPYRIDIN-2-YL-BORONIC ACID;3,5-DICHLORO-2-BROMOPYRIDINE;AKOS BBS-00001365;PYRIDINE, 2-BROMO-3,5-DICHLORO-;2-BROMO-3,5-DICHLOROPYRIDUNE;3,5-DICHLORO-2-BROMOPYRIDINE 98+%;5-Dichloro-2-broMopyridine
• CAS NO: 14482-51-0
• Molecular Formula: C₅H₂BrCl₂N
• Molecular Weight: 226.89
• EINECS: -0
• Product Categories: blocks;Bromides;Pyridines;Pyridines, Pyrimidines, Purines and Pteredines;Pyridine series;Halides
• Mol File: 14482-51-0.mol
• Article Data: 11

Chemical Properties

• Melting Point: 40-42
• Boiling Point: 243.3 °C at 760 mmHg
• Flash Point: 101 °C
• Appearance: Pale brown/Solid
• Density: 1.848 g/cm³
• Vapor Pressure: 5.17mmHg at 25°C
• Refractive Index: 1.508
• Storage Temp.: Inert atmosphere,Room Temperature
• PKA: -2.37±0.10(Predicted)
• CAS DataBase Reference: 2-Bromo-3,5-dichloropyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Bromo-3,5-dichloropyridine(14482-51-0)
• EPA Substance Registry System: 2-Bromo-3,5-dichloropyridine(14482-51-0)

Safety Data

• Hazard Codes: Xi,T
• Statements: 36/37/38-41-37/38-25
• Safety Statements: 26-45-39
• HazardClass: IRRITANT
• Hazardous Substances Data: 14482-51-0(Hazardous Substances Data)

Usage

General Description

2-Bromo-3,5-dichloropyridine is a chemical compound with the molecular formula C5H2BrCl2N. It is a derivative of pyridine, and its structure consists of a pyridine ring with bromine and two chlorine atoms attached at specific positions. 2-Bromo-3,5-dichloropyridine is commonly used in organic synthesis as a building block for the synthesis of pharmaceuticals, agrochemicals, and other fine chemicals. It has also been used as an intermediate in the development of new materials and chemical processes. Due to its versatile reactivity and functionality, 2-Bromo-3,5-dichloropyridine is a valuable compound in the field of chemical research and development. However, it should be handled with care as it is considered hazardous and may cause irritation to the skin, eyes, and respiratory system.

InChI:InChI=1/C5H2BrF2N/c6-5-4(8)1-3(7)2-9-5/h1-2H

Upstream product

• 4214-74-8 3,5-dichloropyridin-2-amine 
• 343781-45-3 4-bromo-3,5-dichloropyridine 
• 16063-70-0 2,3,5-trichloropyridine 
• 81719-53-1 3,5-dichloropyridine-2-carboxylic acid 
• 5437-33-2 3,5-dichloro-1,2-dihydropyridin-2-one 
• 75272-53-6 2,4,4-trichloro-4-formylbutyronitrile 

Downstream Products

• 87394-60-3 4-(3,5-dichloro-2-pyridyl)piperazine 
• 7655-72-3 3,5-dichloro-2-(trifluoromethyl)pyridine 
• 830348-02-2 N-(2-(3,5-dichloropyridin-2-yl)ethyl)-2-(trifluoromethyl)benzamide 
• 85331-33-5 2-Cyano-3,5-dichloropyridine 
• 1073616-31-5 (S)-4-(3-chloro-5-(1,2-dihydroxyethyl)pyridin-2-yl)-4-fluoro-N-(4-trifluoromethylphenyl)piperidine-1-carboxamide 
• 1033610-05-7 7-bromo-6-methoxy-2-(4-methoxyphenyl)-3-(3,4,5-trimethoxybenzoyl)-furo[3,2-b]pyridine 
• 1033609-98-1 6-methoxy-2-(4-methoxyphenyl)-3-(3,4,5-trimethoxybenzoyl)furo[3,2-b]pyridine 
• 1033609-99-2 6-methoxy-2-(4-methoxyphenyl)-3-(3,4,5-trimethoxyphenyl)furo[3,2-b]pyridine 
• 1033610-42-2 7-bromo-3-iodo-6-methoxy-2-(4-methoxyphenyl)-furo[3,2-b]pyridine 
• 1033610-31-9 C₁₅H₁₂INO₃ 
• 1033610-40-0 4-bromo-3,5-dimethoxy-2-(4-methoxyphenylethynyl)pyridine 

Relevant articles and documents

Transition-metal-free decarboxylative halogenation of 2-picolinic acids with dihalomethane under oxygen conditions

A convenient and efficient method for the synthesis of 2-halogen-substituted pyridines is described. The decarboxylative halogenation of 2-picolinic acids with dihalomethane proceeded smoothly via N-chlorocarbene intermediates to afford 2-halogen-substituted pyridines in satisfactory to excellent yields under transition-metal-free conditions. This new type of decarboxylative halogenation is operationally simple and exhibits high functional-group tolerance.

Chiral Hexahalogenated 4,4′-Bipyridines

The preparation of 27 isomers of chiral hexahalogeno-4,4′-bipyridines by means of two complementary methods is described. The first one is convergent and based on the LDA-induced 4,4′-dimerization of trihalopyridines, whereas the second method is divergent and achieved through regioselective halogenation reactions of 4,4′-bipyridine-2,2′-diones. Iodine in 2,2′-positions of the 4,4′-bipyridines was introduced by a copper-catalyzed Finkelstein reaction (Buchwald procedure) performed on 2,2′-dibromo derivatives. Selected compounds of this new family of atropisomeric 4,4′-bipyridines were enantioseparated by high performance liquid chromatography on chiral stationary phases, and the absolute configurations of the separated enantiomers were assigned by using X-ray diffraction analysis. The latter revealed that various halogen bond types are responsible for crystal cohesion.

CHEMICAL COMPOUNDS AND PROCESSES

The present invention relates generally to chemical compounds and methods for their use and preparation. In particular, the invention relates to chemical compounds which may possess useful therapeutic activity, use of these compounds in methods of therapy and the manufacture of medicaments as well as compositions containing these compounds.