Boc-DL-Lys(Cbz)-DL-Lys(Cbz)-NHNH2

Base Information

• Chemical Name: Boc-DL-Lys(Cbz)-DL-Lys(Cbz)-NHNH2
• CAS No.: 62146-52-5
• Molecular Formula: C33H48N6O8
• Molecular Weight: 656.7696
• NSC Number: 170408
• DSSTox Substance ID: DTXSID60305361
• Mol file: 62146-52-5.mol

Synonyms:62146-52-5;NSC170408;DTXSID60305361;NSC-170408;Benzyl tert-butyl {6-[(6-{[(benzyloxy)carbonyl]amino}-1-hydrazinyl-1-oxohexan-2-yl)amino]-6-oxohexane-1,5-diyl}biscarbamate (non-preferred name)

Chemical Property of Boc-DL-Lys(Cbz)-DL-Lys(Cbz)-NHNH2

Chemical Property:

• Vapor Pressure: 3.56E-34mmHg at 25°C
• Boiling Point: 912.3°Cat760mmHg
• Flash Point: 505.5°C
• Density: 1.194g/cm³
• XLogP3: 3.5
• Hydrogen Bond Donor Count: 6
• Hydrogen Bond Acceptor Count: 9
• Rotatable Bond Count: 22
• Exact Mass: 656.35336251
• Heavy Atom Count: 47
• Complexity: 963

Purity/Quality:

99%min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(C)(C)OC(=O)NC(CCCCNC(=O)OCC1=CC=CC=C1)C(=O)NC(CCCCNC(=O)OCC2=CC=CC=C2)C(=O)NN

Technology Process of Boc-DL-Lys(Cbz)-DL-Lys(Cbz)-NHNH2

There total 3 articles about Boc-DL-Lys(Cbz)-DL-Lys(Cbz)-NHNH2 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.1%

Boc-Lys(Z)-Lys(Z)-OBzl (32769-96-3) → Boc-Lys(Z)-Lys(Z)-NHNH2 (62146-52-5)

Guidance literature:

With hydrazine hydrate; In methanol; Ambient temperature;

DOI:10.1248/cpb.40.2694

Reference yield:

N-α-tert-butyloxycarbonyl-N-ε-benzyloxycarbonyl-lysine p-nitrophenyl ester (2389-46-0) → Boc-Lys(Z)-Lys(Z)-NHNH2 (62146-52-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 68 percent / Et₃N / dimethylformamide / Ambient temperature

2: 78.1 percent / 90percent NH₂NH₂*H₂O / methanol / Ambient temperature

With hydrazine hydrate; triethylamine; In methanol; N,N-dimethyl-formamide;

DOI:10.1248/cpb.40.2694

Reference yield:

→ Boc-Lys(Z)-Lys(Z)-NHNH2 (62146-52-5)

Guidance literature:

aus Boc-Lys(-Z)-Lys(-Z)-OMe (2) u.Hydrazinhydrat;

upstream raw materials:

Boc-Lys(Z)-Lys(Z)-OBzl

N-α-tert-butyloxycarbonyl-N-ε-benzyloxycarbonyl-lysine p-nitrophenyl ester

Refernces