6-tert-butylnicotinic acid

Base Information

• Chemical Name: 6-tert-butylnicotinic acid
• CAS No.: 832715-99-8
• Molecular Formula: C10H13NO2
• Molecular Weight: 179.21600
• Hs Code.: 2933399090
• Mol file: 832715-99-8.mol

Synonyms:6-tert-butylpyridine-3-carboxylic acid;

Chemical Property of 6-tert-butylnicotinic acid

Chemical Property:

• PSA: 50.19000
• LogP: 2.07730
• Storage Temp.: Inert atmosphere,Room Temperature

Purity/Quality:

97% ^*data from raw suppliers

6-tert-butylnicotinicacid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 6-tert-butylnicotinic acid

There total 3 articles about 6-tert-butylnicotinic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 4.0%

nicotinic acid (59-67-6) + trimethylpyruvic acid (815-17-8) → 6-(tert-butyl)nicotinic acid (832715-99-8)

Guidance literature:

nicotinic acid; trimethylpyruvic acid; With sulfuric acid; In water; at 20 ℃; for 0.166667h; Inert atmosphere;

With ammonium persulfate; silver nitrate; at 90 ℃; for 2h; Inert atmosphere;

Reference yield:

nicotinic acid (59-67-6) + Trimethylacetic acid (75-98-9) → 6-(tert-butyl)nicotinic acid (832715-99-8)

Guidance literature:

nicotinic acid; Trimethylacetic acid; With sulfuric acid; In water; at 20 ℃; for 0.166667h; Inert atmosphere;

With ammonium peroxydisulfate; silver nitrate; In water; at 90 ℃; Inert atmosphere; Darkness;

Reference yield:

6-tert-butylpyridine-3-carbonitrile (56029-45-9) → 6-(tert-butyl)nicotinic acid (832715-99-8)

Guidance literature:

With hydrogenchloride; In water; at 80 ℃;

upstream raw materials:

6-tert-butylpyridine-3-carbonitrile

nicotinic acid

Trimethylacetic acid

trimethylpyruvic acid

Downstream raw materials:

6-tert-butyl-N-{2-methyl-3-[8-(4-morpholin-4-ylmethyl-phenylamino)-imidazo[1,2-a]pyrazin-6-yl]-phenyl}-nicotinamide

6-tert-butyl-N-(3-(aminosulfonyl)phenyl)pyridine-3-carboxamide