6-tert-butyl-N-{2-methyl-3-[8-(4-morpholin-4-ylmethyl-phenylamino)-imidazo[1,2-a]pyrazin-6-yl]-phenyl}-nicotinamide

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Chemical Name:6-tert-butyl-N-{2-methyl-3-[8-(4-morpholin-4-ylmethyl-phenylamino)-imidazo[1,2-a]pyrazin-6-yl]-phenyl}-nicotinamide
CAS No.:886854-82-6
Molecular Formula:C₃₄H₃₇N₇O₂
Molecular Weight:575.713
Hs Code.:

Synonyms:6-tert-butyl-N-{2-methyl-3-[8-(4-morpholin-4-ylmethyl-phenylamino)-imidazo[1,2-a]pyrazin-6-yl]-phenyl}-nicotinamide

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Chemical Property of 6-tert-butyl-N-{2-methyl-3-[8-(4-morpholin-4-ylmethyl-phenylamino)-imidazo[1,2-a]pyrazin-6-yl]-phenyl}-nicotinamide

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Technology Process of 6-tert-butyl-N-{2-methyl-3-[8-(4-morpholin-4-ylmethyl-phenylamino)-imidazo[1,2-a]pyrazin-6-yl]-phenyl}-nicotinamide

There total 8 articles about 6-tert-butyl-N-{2-methyl-3-[8-(4-morpholin-4-ylmethyl-phenylamino)-imidazo[1,2-a]pyrazin-6-yl]-phenyl}-nicotinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 832715-99-8
6-(tert-butyl)nicotinic acid

: 886854-86-0
[6-(3-amino-2-methyl-phenyl)-imidazo[1,2-a]pyrazin-8-yl]-(4-morpholin-4-ylmethyl-phenyl)-amine

: 886854-82-6
6-tert-butyl-N-{2-methyl-3-[8-(4-morpholin-4-ylmethyl-phenylamino)-imidazo[1,2-a]pyrazin-6-yl]-phenyl}-nicotinamide

Guidance literature:: [6-(3-amino-2-methyl-phenyl)-imidazo[1,2-a]pyrazin-8-yl]-(4-morpholin-4-ylmethyl-phenyl)-amine; With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In ISOPROPYLAMIDE; at 20 ℃; for 0.333333h;

6-(tert-butyl)nicotinic acid; In ISOPROPYLAMIDE; at 20 ℃; for 16h;

Reference yield:

: 59-67-6
nicotinic acid

: 886854-82-6
6-tert-butyl-N-{2-methyl-3-[8-(4-morpholin-4-ylmethyl-phenylamino)-imidazo[1,2-a]pyrazin-6-yl]-phenyl}-nicotinamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: ammonium peroxydisulfate; sulfuric acid / silver nitrate / water / 3 h / 90 °C

2.1: (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / ISOPROPYLAMIDE / 0.33 h / 20 °C

2.2: 16 h / 20 °C

With ammonium peroxydisulfate; sulfuric acid; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; silver nitrate; In ISOPROPYLAMIDE; water;

Reference yield:

: 886854-83-7
4-(6-bromo-imidazo[1,2-a]pyrazin-8-ylamino)-benzoic acid

: 886854-82-6
6-tert-butyl-N-{2-methyl-3-[8-(4-morpholin-4-ylmethyl-phenylamino)-imidazo[1,2-a]pyrazin-6-yl]-phenyl}-nicotinamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / ISOPROPYLAMIDE / 0.33 h / 20 °C

1.2: 16 h / 20 °C

2.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane / 16 h / 95 °C

3.1: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / 20 °C / Heating / reflux

3.2: 0.25 h / 0 °C

4.1: (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / ISOPROPYLAMIDE / 0.33 h / 20 °C

4.2: 16 h / 20 °C

With lithium aluminium tetrahydride; sodium carbonate; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,2-dimethoxyethane; ISOPROPYLAMIDE;