1-Pyrrolidinecarboxylic acid, 5-(3,4-dihydro-5-methyl-2,4-dioxo-1(2H)-pyrimidinyl)-3-(phenylmethoxy) -2-[(phenylmethoxy)methyl]-, 1,1-dimethylethyl ester, (2R,3S,5R)-

Base Information

Chemical Name:1-Pyrrolidinecarboxylic acid, 5-(3,4-dihydro-5-methyl-2,4-dioxo-1(2H)-pyrimidinyl)-3-(phenylmethoxy) -2-[(phenylmethoxy)methyl]-, 1,1-dimethylethyl ester, (2R,3S,5R)-
CAS No.:834895-40-8
Molecular Formula:C29H35N3O6
Molecular Weight:521.613
Hs Code.:

1-Pyrrolidinecarboxylic acid,
5-(3,4-dihydro-5-methyl-2,4-dioxo-1(2H)-pyrimidinyl)-3-(phenylmethoxy)
-2-[(phenylmethoxy)methyl]-, 1,1-dimethylethyl ester, (2R,3S,5R)-

Synonyms:

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-Pyrrolidinecarboxylic acid, 5-(3,4-dihydro-5-methyl-2,4-dioxo-1(2H)-pyrimidinyl)-3-(phenylmethoxy) -2-[(phenylmethoxy)methyl]-, 1,1-dimethylethyl ester, (2R,3S,5R)-

Chemical Property:

Purity/Quality:

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MSDS Files:: SDS file from LookChem

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Technology Process of 1-Pyrrolidinecarboxylic acid, 5-(3,4-dihydro-5-methyl-2,4-dioxo-1(2H)-pyrimidinyl)-3-(phenylmethoxy) -2-[(phenylmethoxy)methyl]-, 1,1-dimethylethyl ester, (2R,3S,5R)-

There total 10 articles about 1-Pyrrolidinecarboxylic acid, 5-(3,4-dihydro-5-methyl-2,4-dioxo-1(2H)-pyrimidinyl)-3-(phenylmethoxy) -2-[(phenylmethoxy)methyl]-, 1,1-dimethylethyl ester, (2R,3S,5R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

: 65-71-4,28806-14-6,691841-57-3
thymin

: 834895-39-5
acetic acid (4S,5R)-4-benzyloxy-5-benzyloxymethyl-1-(tert-butoxycarbonyl)pyrrolidin-2-yl ester

: 834895-40-8
3-benzyloxy-2-benzyloxymethyl-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-pyrrolidine-1-carboxylic acid tert-butyl ester

: 834895-41-9
3-benzyloxy-2-benzyloxymethyl-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-pyrrolidine-1-carboxylic acid tert-butyl ester

Guidance literature:: With ammonium sulfate; tin(IV) chloride; 1,1,1,3,3,3-hexamethyl-disilazane; In acetonitrile; at -25 ℃; for 1h;
DOI:10.1016/j.tetasy.2004.10.030

Reference yield:

: 254730-07-9
(S)-4-benzyloxy-1-(4-methoxybenzyl)-2,5-pyrrolidinedione

: 834895-40-8
3-benzyloxy-2-benzyloxymethyl-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-pyrrolidine-1-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 11 steps

1.1: n-butyllithium / tetrahydrofuran; hexane / 2 h / 0 °C

1.2: tetrahydrofuran; hexane / 0.33 h / -78 °C

2.1: 1.63 g / triethylsilane; BF₃*Et₂O / CH₂Cl₂ / -78 - 20 °C

3.1: NaIO₄; RuCl₃*xH₂O / H₂O; acetonitrile; CCl₄ / 0.08 h

4.1: 1.24 g / diethyl ether; tetrahydrofuran / 0 °C

5.1: 95 percent / anhydrous calcium chloride; sodium borohydride / ethanol; tetrahydrofuran / 3 h / 20 °C

6.1: 84 percent / sodium hydride / tetrahydrofuran; various solvent(s) / 40 h / -20 °C

7.1: 84 percent / cerium(IV) ammonium nitrate / acetonitrile; H₂O / 3 h / 20 °C

8.1: 95 percent / DMAP / acetonitrile / 1 h

9.1: 99 percent / DIBAL-H / tetrahydrofuran; toluene / 0.5 h / -78 °C

10.1: DMAP; triethylamine / CH₂Cl₂ / 0 - 23 °C

11.1: 31 percent / (NH₄)2SO₄; hexamethyldisilazane; SnCl₄ / acetonitrile / 1 h / -25 °C

With triethylsilane; dmap; ruthenium trichloride; ammonium sulfate; sodium tetrahydroborate; sodium periodate; n-butyllithium; ammonium cerium(IV) nitrate; boron trifluoride diethyl etherate; tin(IV) chloride; sodium hydride; diisobutylaluminium hydride; triethylamine; 1,1,1,3,3,3-hexamethyl-disilazane; calcium chloride; In tetrahydrofuran; tetrachloromethane; diethyl ether; ethanol; hexane; dichloromethane; water; toluene; acetonitrile;
DOI:10.1016/j.tetasy.2004.10.030

Reference yield:

: 834895-36-2
(4S,5R)-4-benzyloxy-5-benzyloxymethylpyrrolidin-2-one

: 834895-40-8
3-benzyloxy-2-benzyloxymethyl-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-pyrrolidine-1-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 95 percent / DMAP / acetonitrile / 1 h

2: 99 percent / DIBAL-H / tetrahydrofuran; toluene / 0.5 h / -78 °C

3: DMAP; triethylamine / CH₂Cl₂ / 0 - 23 °C

4: 31 percent / (NH₄)2SO₄; hexamethyldisilazane; SnCl₄ / acetonitrile / 1 h / -25 °C

With dmap; ammonium sulfate; tin(IV) chloride; diisobutylaluminium hydride; triethylamine; 1,1,1,3,3,3-hexamethyl-disilazane; In tetrahydrofuran; dichloromethane; toluene; acetonitrile;
DOI:10.1016/j.tetasy.2004.10.030