Methyl 4-(hydroxyMethyl)tetrahydro-2H-pyran-4-carboxylat

Base Information

• Chemical Name: Methyl 4-(hydroxyMethyl)tetrahydro-2H-pyran-4-carboxylat
• CAS No.: 834914-37-3
• Molecular Formula: C8H14O4
• Molecular Weight: 174.19400
• Mol file: 834914-37-3.mol

Synonyms:

Chemical Property of Methyl 4-(hydroxyMethyl)tetrahydro-2H-pyran-4-carboxylat

Chemical Property:

• PSA: 55.76000
• LogP: -0.05150

Purity/Quality:

98% ^*data from raw suppliers

Methyl4-(hydroxymethyl)oxane-4-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Methyl 4-(hydroxyMethyl)tetrahydro-2H-pyran-4-carboxylat

There total 2 articles about Methyl 4-(hydroxyMethyl)tetrahydro-2H-pyran-4-carboxylat which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

4-formyltetrahydro-2H-pyran-4-carboxylic acid methyl ester (907607-89-0) → methyl 4-(hydroxymethyl)tetrahydro-2H-pyran-4-carboxylate (834914-37-3)

Guidance literature:

With sodium tetrahydroborate; In methanol; water; at 0 - 20 ℃; for 1h; Inert atmosphere;

DOI:10.1002/cmdc.200900389

Reference yield:

4,4-dimethyl dihydro-2H-pyran-4,4(3H)-dicarboxylate (149777-00-4) → methyl 4-(hydroxymethyl)tetrahydro-2H-pyran-4-carboxylate (834914-37-3)

Guidance literature:

With lithium tri-tert-butoxyaluminum hydride; In tetrahydrofuran; at 20 ℃; for 1h;

Reference yield: 91.0%

methyl 4-(hydroxymethyl)tetrahydro-2H-pyran-4-carboxylate (834914-37-3) + benzyl bromide (100-39-0) → C15H20O4 (1352276-39-1)

Guidance literature:

methyl 4-(hydroxymethyl)tetrahydro-2H-pyran-4-carboxylate; With sodium hydride; In tetrahydrofuran; mineral oil; at 20 ℃; for 0.5h; Inert atmosphere;

benzyl bromide; In tetrahydrofuran; mineral oil; at 20 ℃; Inert atmosphere;

DOI:10.1002/cmdc.200900389

upstream raw materials:

4,4-dimethyl dihydro-2H-pyran-4,4(3H)-dicarboxylate

4-formyltetrahydro-2H-pyran-4-carboxylic acid methyl ester

Downstream raw materials:

C₁₅H₂₀O₄

Refernces

• 1、 -. "IMIDAZOLE DERIVATIVES". . . Retrieved 2013/02/27.
• 2、 -. "NITROGEN-CONTAINING HETEROCYCLIC COMPOUND AND PHARMACEUTICAL APPLICATION THEREOF". Page/Page column 77-78. . Retrieved 2010/11/26.