Benzo(2'-(1-benzyl-4-piperidyl))hydrazide

Base Information

• Chemical Name: Benzo(2'-(1-benzyl-4-piperidyl))hydrazide
• CAS No.: 52313-55-0
• Molecular Formula: C19H23N3O
• Molecular Weight: 309.411
• European Community (EC) Number: 257-838-7
• NSC Number: 76551
• UNII: BVW2YA174O
• DSSTox Substance ID: DTXSID70200338
• Nikkaji Number: J295.635G
• Wikidata: Q83073424
• ChEMBL ID: CHEMBL1868255
• Mol file: 52313-55-0.mol

Synonyms:52313-55-0;Benzo(2'-(1-benzyl-4-piperidyl))hydrazide;n'-(1-benzylpiperidin-4-yl)benzohydrazide;BVW2YA174O;MLS002693989;EINECS 257-838-7;NSC 76551;NSC-76551;BENZO[2'-[1-BENZYL-4-PIPERIDYL]]HYDRAZIDE;Benzoic acid, 2-(1-(phenylmethyl)-4-piperidinyl)hydrazide;HMS3085K16;NSC76551;UNII-BVW2YA174O;SCHEMBL8553564;CHEMBL1868255;DTXSID70200338;AKOS024332136;SMR001559924;4-(BENZOYLHYDRAZINO)-1-BENZYLPIPERIDINE;N'-[1-(Phenylmethyl)-4-piperidinyl]benzohydrazide

Chemical Property of Benzo(2'-(1-benzyl-4-piperidyl))hydrazide

Chemical Property:

• Boiling Point: 426°Cat760mmHg
• Flash Point: 211.4°C
• Density: 1.16g/cm³
• XLogP3: 3
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 5
• Exact Mass: 309.184112366
• Heavy Atom Count: 23
• Complexity: 354

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CN(CCC1NNC(=O)C2=CC=CC=C2)CC3=CC=CC=C3

Technology Process of Benzo(2'-(1-benzyl-4-piperidyl))hydrazide

There total 3 articles about Benzo(2'-(1-benzyl-4-piperidyl))hydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.7%

1-phenylmethyl-4-piperidone (3612-20-2) + benzoic acid hydrazide (613-94-5) → benzo[2'-(1-benzyl-4-piperidyl)]hydrazide (52313-55-0)

Guidance literature:

With sodium borohydrid; In methanol; water;

Reference yield:

N'-(1-benzylpiperidin-4-ylidene)benzohydrazide (52313-53-8) → benzo[2'-(1-benzyl-4-piperidyl)]hydrazide (52313-55-0)

Guidance literature:

With sodium tetrahydroborate; In methanol; for 2h; Cooling with ice;

DOI:10.1021/jm9012642

Reference yield:

→ benzo[2'-(1-benzyl-4-piperidyl)]hydrazide (52313-55-0)

Guidance literature:

2-(1-Benzyl-4-piperidyliden)-benzoesaeurehydrazid, Diisobutylaluminiumhydrid, Red.;

upstream raw materials:

1-phenylmethyl-4-piperidone

benzoic acid hydrazide

N'-(1-benzylpiperidin-4-ylidene)benzohydrazide

Downstream raw materials:

(1-benzyl-piperidin-4-yl)-hydrazine dihydrochloride

benzoic acid

Refernces

• 1、 Verheijen, Jeroen C.,Richard, David J.,Curran, Kevin,Kaplan, Joshua,Lefever, Mark,Nowak, Pawel,Malwitz, David J.,Brooijmans, Natasja,Toral-Barza, Lourdes,Zhang, Wei-Guo,Lucas, Judy,Hollander, Irwin,Ayral-Kaloustian, Semiramis,Mansour, Tarek S.,Yu, Ker,Zask, Arie. "Discovery of 4-morpholino-6-aryl-1H-pyrazolo[3,4-d]pyrimidines as highly potent and selective ATP-competitive inhibitors of the mammalian target of rapamycin (mTOR): Optimization of the 6-aryl substituent". experimental part. p. 8010 - 8024. Retrieved 2010/07/04.
• 2、 -. "SULFONYLUREIDOPYRAZOLE DERIVATIVES". . . Retrieved 2008/06/13.