1-BENZYL-4-HYDRAZINOPIPERIDINE TRIHYDROCHLORIDE

Base Information

• Chemical Name: 1-BENZYL-4-HYDRAZINOPIPERIDINE TRIHYDROCHLORIDE
• CAS No.: 1185303-13-2
• Molecular Formula: C₁₂H₁₉N₃*2ClH
• Molecular Weight: 278.225
• Mol file: 1185303-13-2.mol

Synonyms:

Chemical Property of 1-BENZYL-4-HYDRAZINOPIPERIDINE TRIHYDROCHLORIDE

Chemical Property:

Purity/Quality:

98%min ^*data from raw suppliers

1-Benzyl-4-hydrazinopiperidinetrihydrochloride ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi

MSDS Files:

Useful:

Technology Process of 1-BENZYL-4-HYDRAZINOPIPERIDINE TRIHYDROCHLORIDE

There total 6 articles about 1-BENZYL-4-HYDRAZINOPIPERIDINE TRIHYDROCHLORIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.2%

benzo[2'-(1-benzyl-4-piperidyl)]hydrazide (52313-55-0) → (1-benzyl-piperidin-4-yl)-hydrazine dihydrochloride (1185303-13-2)

Guidance literature:

With hydrogenchloride; In methanol; water;

Reference yield:

benzo[2'-(1-benzyl-4-piperidyl)]hydrazide (52313-55-0) → (1-benzyl-piperidin-4-yl)-hydrazine dihydrochloride (1185303-13-2) + benzoic acid (65-85-0,8013-63-6)

Guidance literature:

With hydrogenchloride; water; Reflux;

DOI:10.1021/jm9012642

Reference yield:

tert-butyl 2-(1-benzylpiperidin-4-yl)hydrazinecarboxylate (917807-06-8) → (1-benzyl-piperidin-4-yl)-hydrazine dihydrochloride (1185303-13-2)

Guidance literature:

With hydrogenchloride; In methanol; at 20 ℃; for 108h; Cooling with ice;

upstream raw materials:

benzo[2'-(1-benzyl-4-piperidyl)]hydrazide

tert-butyl 2-(1-benzylpiperidin-4-yl)hydrazinecarboxylate

1-phenylmethyl-4-piperidone

benzoic acid hydrazide

Downstream raw materials:

1-benzyl-4-(5-isopropyl-3-methyl-1H-1,2,4-triazol-1-yl)piperidine

1-benzyl-4-(3-ethyl-5-methyl-1H-1,2,4-triazol-1-yl)piperidine

C₂₂H₂₄N₄O₂

1,1-dimethylethyl 3-oxo-2-[1-(phenylmethyl)-4-piperidinyl]-3,3a,4,5,7,8-hexahydropyrazolo[3,4-d]azepine-6(2H)-carboxylate

Refernces

• 1、 Verheijen, Jeroen C.,Richard, David J.,Curran, Kevin,Kaplan, Joshua,Lefever, Mark,Nowak, Pawel,Malwitz, David J.,Brooijmans, Natasja,Toral-Barza, Lourdes,Zhang, Wei-Guo,Lucas, Judy,Hollander, Irwin,Ayral-Kaloustian, Semiramis,Mansour, Tarek S.,Yu, Ker,Zask, Arie. "Discovery of 4-morpholino-6-aryl-1H-pyrazolo[3,4-d]pyrimidines as highly potent and selective ATP-competitive inhibitors of the mammalian target of rapamycin (mTOR): Optimization of the 6-aryl substituent". experimental part. p. 8010 - 8024. Retrieved 2010/07/04.
• 2、 -. "THIENOPYRIMIDINE AND PYRAZOLOPYRIMIDINE COMPOUNDS AND THEIR USE AS MTOR KINASE AND PI3 KINASE INHIBITORS". Page/Page column 59. . Retrieved 2009/04/24.