N-(2-Bromopyridin-3-yl)pivalamide

Base Information

• Chemical Name: N-(2-Bromopyridin-3-yl)pivalamide
• CAS No.: 835882-02-5
• Molecular Formula: C10H13BrN2O
• Molecular Weight: 257.13
• Hs Code.: 2933399090
• Mol file: 835882-02-5.mol

Synonyms:2-Bromo-3-N-pivaloyl-aminopyridine;3-pivaloylamino-2-bromopyridine;N-(2-bromopyridin-3-yl)trimethylacetamide;2-bromo-3-(pivaloylamino)pyridine;N-(2-Bromopyridin-3-yl)pivalamide;

Chemical Property of N-(2-Bromopyridin-3-yl)pivalamide

Chemical Property:

• Vapor Pressure: 5.85E-06mmHg at 25°C
• Melting Point: 47 °C
• Boiling Point: 379.4oC at 760 mmHg
• PKA: 13.26±0.70(Predicted)
• Flash Point: 183.3oC
• PSA: 41.99000
• Density: 1.416g/cm3
• LogP: 2.90170
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

2-Bromo-3-n-pivaloyl-aminopyridine ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xn
• Statements: 22

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-(2-Bromopyridin-3-yl)pivalamide

There total 1 articles about N-(2-Bromopyridin-3-yl)pivalamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

3-amino-2-bromopyridine (39856-58-1) + pivaloyl chloride (3282-30-2) → N-(2-bromopyridin-3-yl)trimethylacetamide (835882-02-5)

Guidance literature:

With triethylamine; In dichloromethane; at 0 - 20 ℃; for 3h;

Reference yield: 39.0%

N-(2-bromopyridin-3-yl)trimethylacetamide (835882-02-5) + N-methoxy-N-methylbenzamide (6919-61-5) → (3-aminopyridin-2-yl)(phenyl)methanone (3810-13-7)

Guidance literature:

N-(2-bromopyridin-3-yl)trimethylacetamide; With n-butyllithium; In tetrahydrofuran; at -78 ℃; for 1h;

N-methoxy-N-methylbenzamide; In tetrahydrofuran; at -78 - 20 ℃;

With hydrogenchloride; In methanol; water; at 100 ℃; for 16h;

Reference yield:

N-(2-bromopyridin-3-yl)trimethylacetamide (835882-02-5) + N-methoxy-N-methylbenzamide (6919-61-5) → C17H18N2O2

Guidance literature:

N-(2-bromopyridin-3-yl)trimethylacetamide; With n-butyllithium; In tetrahydrofuran; at -78 ℃; for 3h;

N-methoxy-N-methylbenzamide; In tetrahydrofuran; Further stages.;

DOI:10.1016/j.bmcl.2008.01.088

upstream raw materials:

3-amino-2-bromopyridine

pivaloyl chloride

Downstream raw materials:

(3-aminopyridin-2-yl)(phenyl)methanone

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