2H-Isoindole-2-carboxylic acid, 1,3-dihydro-4,5-dimethoxy-1-[[6-(2-methoxyethyl)-1,3-benzodioxol-5-yl] methyl]-3-oxo-, (1S,2R)-2-(1-methyl-1-phenylethyl)cyclohexyl ester, (1S)-

Base Information

Chemical Name:2H-Isoindole-2-carboxylic acid, 1,3-dihydro-4,5-dimethoxy-1-[[6-(2-methoxyethyl)-1,3-benzodioxol-5-yl] methyl]-3-oxo-, (1S,2R)-2-(1-methyl-1-phenylethyl)cyclohexyl ester, (1S)-
CAS No.:837361-52-1
Molecular Formula:C37H43NO8
Molecular Weight:629.75
Hs Code.:

2H-Isoindole-2-carboxylic acid,
1,3-dihydro-4,5-dimethoxy-1-[[6-(2-methoxyethyl)-1,3-benzodioxol-5-yl]
methyl]-3-oxo-, (1S,2R)-2-(1-methyl-1-phenylethyl)cyclohexyl ester,
(1S)-

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Chemical Property of 2H-Isoindole-2-carboxylic acid, 1,3-dihydro-4,5-dimethoxy-1-[[6-(2-methoxyethyl)-1,3-benzodioxol-5-yl] methyl]-3-oxo-, (1S,2R)-2-(1-methyl-1-phenylethyl)cyclohexyl ester, (1S)-

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Technology Process of 2H-Isoindole-2-carboxylic acid, 1,3-dihydro-4,5-dimethoxy-1-[[6-(2-methoxyethyl)-1,3-benzodioxol-5-yl] methyl]-3-oxo-, (1S,2R)-2-(1-methyl-1-phenylethyl)cyclohexyl ester, (1S)-

There total 10 articles about 2H-Isoindole-2-carboxylic acid, 1,3-dihydro-4,5-dimethoxy-1-[[6-(2-methoxyethyl)-1,3-benzodioxol-5-yl] methyl]-3-oxo-, (1S,2R)-2-(1-methyl-1-phenylethyl)cyclohexyl ester, (1S)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

: 837361-51-0
5-bromomethyl-6-(2-methoxyethyl)benzo[1,3]dioxole

: 837361-46-3
6,7-dimethoxy-N-[(((1S,2R)-2-(1-methyl-1-phenylethyl)cyclohexyl)oxy)carbonyl]-2,3-dihydroisoindol-1-one

: 837361-52-1
(3S)-4,5-dimethoxy-1-[6-(2-methoxyethyl)benzo[1,3]dioxol-5-ylmethyl]-3-oxo-1,3-dihydroisoindole-2-carboxylic acid (1S,2R)-2-(1-methyl-1-phenylethyl)cyclohexyl ester

Guidance literature:: With sodium hexamethyldisilazane; In tetrahydrofuran; at -78 ℃;
DOI:10.1021/ol047824w

Reference yield:

: 837361-48-5
[6-(2-methoxyvinyl)benzo[1,3]dioxol-5-yl]methanol

: 837361-52-1
(3S)-4,5-dimethoxy-1-[6-(2-methoxyethyl)benzo[1,3]dioxol-5-ylmethyl]-3-oxo-1,3-dihydroisoindole-2-carboxylic acid (1S,2R)-2-(1-methyl-1-phenylethyl)cyclohexyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 82 percent / H₂ / Pd/C

2: PBr₃ / diethyl ether

3: 56 percent / sodium bis(trimethylsilyl)amide / tetrahydrofuran / -78 °C

With hydrogen; sodium hexamethyldisilazane; phosphorus tribromide; palladium on activated charcoal; In tetrahydrofuran; diethyl ether;
DOI:10.1021/ol047824w

Reference yield:

: 59084-77-4
methyl 6-bromo-2,3-dimethoxybenzoate

: 837361-52-1
(3S)-4,5-dimethoxy-1-[6-(2-methoxyethyl)benzo[1,3]dioxol-5-ylmethyl]-3-oxo-1,3-dihydroisoindole-2-carboxylic acid (1S,2R)-2-(1-methyl-1-phenylethyl)cyclohexyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 61 percent / dimethylformamide

2: 80 percent / H₂ / Raney nickel / ethanol

3: 75 percent / n-butyllithium

4: 56 percent / sodium bis(trimethylsilyl)amide / tetrahydrofuran / -78 °C

With n-butyllithium; hydrogen; sodium hexamethyldisilazane; nickel; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide;
DOI:10.1021/ol047824w