59084-77-4

Upstream product

• 60555-93-3 6-bromo-2,3-dimethoxybenzoic acid 
• 74-88-4 methyl iodide 
• 53811-50-0 6-bromo-2,3-dimethoxybenzaldehyde 
• 77-78-1 dimethyl sulfate 

Downstream Products

• 59084-78-5 Methyl-6-cyano-2,3-dimethoxybenzoat 
• 837361-46-3 6,7-dimethoxy-N-[(((1S,2R)-2-(1-methyl-1-phenylethyl)cyclohexyl)oxy)carbonyl]-2,3-dihydroisoindol-1-one 
• 837361-52-1 (3S)-4,5-dimethoxy-1-[6-(2-methoxyethyl)benzo[1,3]dioxol-5-ylmethyl]-3-oxo-1,3-dihydroisoindole-2-carboxylic acid (1S,2R)-2-(1-methyl-1-phenylethyl)cyclohexyl ester 
• 628328-75-6 methyl 6-[3-(1-hydroxy-6,7-methylenedioxynaphthyl)]-2,3-dimethoxybenzoate 

Relevant academic research and scientific papers

Concise synthesis of arnottin I and (-)-arnottin II

Application of the Buchwald protocol to the coupling of o-bromobenzoates and 1-tetralones directly affords benzodihydronaphthopyrones with a fused tetracyclic system. Aromatization of the 7,8-dimethoxy-2,3-methylenedioxy derivative yielded arnottin I, whe

Method for synthesizing 6-6 fused ring structure in berberine and ebony natural product

The invention discloses a method for synthesizing a 6-6 fused ring structure in berberine and ebony natural products. The method comprises the step of carrying out intramolecular tandem cyclization reaction on conjugated enyne ester with a structure shown in a formula II in a solvent, so that the 6-6 fused ring structure shown in a formula I is obtained, a specific reaction formula is described in the specification, wherein R1 and R2 are respectively independently selected from hydrogen, alkyl, naphthenic base, aryl and heterocyclic radical; or R1 and R2 form a saturated or unsaturated carboatomic ring or heterocyclic ring together; R3 and R4 are respectively independently selected from hydrogen, alkyl, naphthenic base, aryl and heterocyclic radical; or R3 and R4 form a saturated or unsaturated carboatomic ring or heterocyclic ring together; R is selected from C1-C4 alkyl; P is an amino-protecting group. The method disclosed by the invention has the advantages of simple operation, safety, environmental friendliness, low production cost, high yield and adaptability to large scale production and has important value in promotion of extensive use of the compound in the filed of medicines.