(4,6-DICHLORO-PYRIDIN-2-YL)-HYDRAZINE

Base Information

• Chemical Name: (4,6-DICHLORO-PYRIDIN-2-YL)-HYDRAZINE
• CAS No.: 837365-03-4
• Molecular Formula: C5H5Cl2N3
• Molecular Weight: 178.021
• Mol file: 837365-03-4.mol

Synonyms:

Chemical Property of (4,6-DICHLORO-PYRIDIN-2-YL)-HYDRAZINE

Chemical Property:

• Melting Point: 170-172 °C(Solv: ethyl acetate (141-78-6))
• Boiling Point: 225.2±50.0 °C(Predicted)
• PKA: 8.37±0.70(Predicted)
• PSA: 50.94000
• Density: 1.63±0.1 g/cm3(Predicted)
• LogP: 2.44730

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (4,6-DICHLORO-PYRIDIN-2-YL)-HYDRAZINE

There total 5 articles about (4,6-DICHLORO-PYRIDIN-2-YL)-HYDRAZINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2,4-dichloro-6-hydrazino-3-(trimethylsilyl)pyridine → 2,4-dichloro-6-hydrazinopyridine (837365-03-4)

Guidance literature:

With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 25 ℃; for 2h;

DOI:10.1021/jo047962z

Reference yield:

2,4,6-trichloro-3-(trimethylsilyl)pyridine (837365-00-1) → 2,4-dichloro-6-hydrazinopyridine (837365-03-4)

Guidance literature:

Multi-step reaction with 2 steps

1: H₂NNH₂*H₂O / tetrahydrofuran / 20 h / 50 °C

2: 6.41 g / tetrabutylammonium fluoride trihydrate / tetrahydrofuran / 2 h / 25 °C

With tetrabutyl ammonium fluoride; hydrazine hydrate; In tetrahydrofuran;

DOI:10.1021/jo047962z

Reference yield:

2,6-dichloropyridine (2402-78-0) → 2,4-dichloro-6-hydrazinopyridine (837365-03-4)

Guidance literature:

Multi-step reaction with 5 steps

1.1: BuLi / tetrahydrofuran; hexane / 0.75 h / -75 °C

1.2: 64 percent / I₂ / tetrahydrofuran; hexane / 0.25 h / -75 °C

2.1: isobutylmagnesium chloride / tetrahydrofuran / 0.75 h / 0 °C

2.2: 94 percent / N-chlorosuccinimide / tetrahydrofuran / 0.75 h

3.1: BuLi / tetrahydrofuran; hexane / 0.75 h / -75 °C

3.2: 92 percent / tetrahydrofuran; hexane

4.1: H₂NNH₂*H₂O / tetrahydrofuran / 20 h / 50 °C

5.1: 6.41 g / tetrabutylammonium fluoride trihydrate / tetrahydrofuran / 2 h / 25 °C

With n-butyllithium; 2-methylpropylmagnesium chloride; tetrabutyl ammonium fluoride; hydrazine hydrate; In tetrahydrofuran; hexane;

DOI:10.1021/jo047962z

upstream raw materials:

2,4,6-trichloro-3-(trimethylsilyl)pyridine

2,6-dichloropyridine

2,4,6-trichloropyridine

2,6-dichloro-4-iodopyridine

Downstream raw materials:

2-chloro-N,N-dimethylpyridin-4-amine

2,4-dichloropyridine