2-Chloro-N,N-dimethylpyridin-4-amine

Base Information

• Chemical Name: 2-Chloro-N,N-dimethylpyridin-4-amine
• CAS No.: 59047-70-0
• Molecular Formula: C7H9ClN2
• Molecular Weight: 156.61276
• DSSTox Substance ID: DTXSID20450760
• Nikkaji Number: J1.696.294E
• Wikidata: Q82270576
• Mol file: 59047-70-0.mol

Synonyms:2-CHLORO-N,N-DIMETHYLPYRIDIN-4-AMINE;59047-70-0;2-Chloro-4-(dimethylamino)pyridine;(2-Chloro-pyridin-4-yl)-dimethyl-amine;benzenesulfonylazide;SCHEMBL1671876;DTXSID20450760;HQNSWBRZIOYGAW-UHFFFAOYSA-N;(2-chloropyridin-4-yl)dimethylamine;AKOS006289595;CS-W001602;MB06813;s11986;FT-0762572;A901545;F1908-2700

Chemical Property of 2-Chloro-N,N-dimethylpyridin-4-amine

Chemical Property:

• PSA: 16.13000
• LogP: 1.80100
• XLogP3: 1.9
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 156.0454260
• Heavy Atom Count: 10
• Complexity: 106

Purity/Quality:

97% ^*data from raw suppliers

2-chloro-N,N-dimethylpyridin-4-amine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CN(C)C1=CC(=NC=C1)Cl

Technology Process of 2-Chloro-N,N-dimethylpyridin-4-amine

There total 10 articles about 2-Chloro-N,N-dimethylpyridin-4-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

dmap (1122-58-3) → 2-chloro-N,N-dimethylpyridin-4-amine (59047-70-0)

Guidance literature:

dmap; With n-butyllithium; 2-(N,N-dimethylamino)ethanol; In hexane; at 0 ℃; for 1h;

With hexachloroethane; In hexane; at -78 - 0 ℃; for 1.5h; Further stages.;

DOI:10.1021/jo016064p

Reference yield: 88.0%

2,4-dichloropyridine (26452-80-2) + dimethyl amine (124-40-3) → 2-chloro-N,N-dimethylpyridin-4-amine (59047-70-0)

Guidance literature:

In water; at 50 ℃; for 20h;

DOI:10.1021/jo047962z

Reference yield: 70.0%

2-chloro-4-bromopyridine (73583-37-6) + N,N-dimethylammonium chloride (506-59-2) → 2-chloro-N,N-dimethylpyridin-4-amine (59047-70-0)

Guidance literature:

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; sodium t-butanolate; In toluene; at 90 ℃; for 4h; Schlenk technique; Inert atmosphere; Sealed tube;

upstream raw materials:

dmap

2,4-dichloropyridine

dimethyl amine

2,4,6-trichloro-3-(trimethylsilyl)pyridine

Downstream raw materials:

C₂₈H₄₃N₅O₄S

C₂₃H₃₆N₄O₃S

C₂₃H₃₈N₄O₃S

C₂₇H₄₂N₄O₃S