Technology Process of Benzenepropanol, 3-bromo-4-hydroxy-5-(trifluoromethyl)-
There total 7 articles about Benzenepropanol, 3-bromo-4-hydroxy-5-(trifluoromethyl)- which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
pyridinium hydrobromide perbromide;
In
chloroform;
at 20 ℃;
for 1.5h;
DOI:10.1246/bcsj.77.2257
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 81 percent / tetrahydrofuran / 20 - 55 °C
2: 1.66 g / hydrogen / Pd/C / methanol / 5 h / 20 °C
3: 95 percent / LiAlH4 / tetrahydrofuran / 0.42 h / 20 °C
4: 96 percent / pyridinium tribromide / CHCl3 / 1.5 h / 20 °C
With
lithium aluminium tetrahydride; hydrogen; pyridinium hydrobromide perbromide;
palladium on activated charcoal;
In
tetrahydrofuran; methanol; chloroform;
1: Wittig reaction;
DOI:10.1246/bcsj.77.2257
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 26.5 g / dimethylformamide / 26 h / 130 °C
2: 82 percent / DIBAL-H / toluene / 0.25 h / -78 °C
3: 81 percent / tetrahydrofuran / 20 - 55 °C
4: 1.66 g / hydrogen / Pd/C / methanol / 5 h / 20 °C
5: 95 percent / LiAlH4 / tetrahydrofuran / 0.42 h / 20 °C
6: 96 percent / pyridinium tribromide / CHCl3 / 1.5 h / 20 °C
With
lithium aluminium tetrahydride; hydrogen; diisobutylaluminium hydride; pyridinium hydrobromide perbromide;
palladium on activated charcoal;
In
tetrahydrofuran; methanol; chloroform; N,N-dimethyl-formamide; toluene;
3: Wittig reaction;
DOI:10.1246/bcsj.77.2257