5H-Cyclopenta[d]pyridazine, 5-[[[(1,1-dimethylethyl)dimethylsilyl]oxy]methyl]-6,7-dihydro-7-methylene- 1,4-diphenyl-

Base Information

• Chemical Name: 5H-Cyclopenta[d]pyridazine, 5-[[[(1,1-dimethylethyl)dimethylsilyl]oxy]methyl]-6,7-dihydro-7-methylene- 1,4-diphenyl-
• CAS No.: 839712-89-9
• Molecular Formula: C27H32N2OSi
• Molecular Weight: 428.649
• Mol file: 839712-89-9.mol

Synonyms:

Chemical Property of 5H-Cyclopenta[d]pyridazine, 5-[[[(1,1-dimethylethyl)dimethylsilyl]oxy]methyl]-6,7-dihydro-7-methylene- 1,4-diphenyl-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5H-Cyclopenta[d]pyridazine, 5-[[[(1,1-dimethylethyl)dimethylsilyl]oxy]methyl]-6,7-dihydro-7-methylene- 1,4-diphenyl-

There total 8 articles about 5H-Cyclopenta[d]pyridazine, 5-[[[(1,1-dimethylethyl)dimethylsilyl]oxy]methyl]-6,7-dihydro-7-methylene- 1,4-diphenyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

(+/-)-cis-{7-[(tert-butyldimethylsilyloxy)methyl]-1,4-diphenyl-6,7-dihydro-5H-cyclopenta[d]pyridazin-5-yl}methyl mesylate → (+/-)-cis-5-[(tert-butyldimethylsilyloxy)methyl]-7-methylidene-1,4-diphenyl-6,7-dihydro-5H-cyclopenta[d]pyridazine (839712-89-9)

Guidance literature:

With 1,8-diazabicyclo[5.4.0]undec-7-ene; In benzene; at 20 - 50 ℃; for 18h;

DOI:10.1055/s-2007-983827

Reference yield: 59.0%

C28H36N2O4SSi + 2-amino-6-chloropurine (10310-21-1) → (±)-cis-7-(tert-butyldimethylsilyloxymethyl)-5-(2-amino-6-chloro-9H-purin-9-ylmethyl)-1,4-diphenyl-6,7-dihydro-5H-cyclopenta[d]pyridazine + (+/-)-cis-5-[(tert-butyldimethylsilyloxy)methyl]-7-methylidene-1,4-diphenyl-6,7-dihydro-5H-cyclopenta[d]pyridazine (839712-89-9)

Guidance literature:

2-amino-6-chloropurine; With 18-crown-6 ether; sodium hydride; In N,N-dimethyl-formamide; at 55 ℃; for 1h; Inert atmosphere;

C₂₈H₃₆N₂O₄SSi; In N,N-dimethyl-formamide; at 55 ℃; for 24h; Inert atmosphere;

DOI:10.1002/minf.200900033

Reference yield: 20.0%

6-chloropurine (87-42-3) + (+/-)-cis-{7-[(tert-butyldimethylsilyloxy)methyl]-1,4-diphenyl-6,7-dihydro-5H-cyclopenta[d]pyridazin-5-yl}methyl mesylate → (+/-)-cis-5-[(tert-butyldimethylsilyloxy)methyl]-7-methylidene-1,4-diphenyl-6,7-dihydro-5H-cyclopenta[d]pyridazine (839712-89-9) + (+/-)-cis-5-[(tert-butyldimethylsilyloxy)methyl]-7-[(6-chloro-9H-purin-9-yl)methyl]-1,4-diphenyl-6,7-dihydro-5H-cyclopenta[d]pyridazine

Guidance literature:

6-chloropurine; With 18-crown-6 ether; sodium hydride; In N,N-dimethyl-formamide; at 55 ℃; for 1.5h;

(+/-)-cis-{7-[(tert-butyldimethylsilyloxy)methyl]-1,4-diphenyl-6,7-dihydro-5H-cyclopenta[d]pyridazin-5-yl}methyl mesylate; In N,N-dimethyl-formamide; at 55 ℃; for 24h;

DOI:10.1055/s-2004-834870

upstream raw materials:

6-chloropurine

tert-butyldimethylsilyl chloride

2-amino-6-chloropurine