6-chloro-N-(2-cyclopropylethyl)pyridazine-3-carboxaMide

Base Information

• Chemical Name: 6-chloro-N-(2-cyclopropylethyl)pyridazine-3-carboxaMide
• CAS No.: 840488-85-9
• Molecular Formula: C10H12ClN3O
• Molecular Weight: 225.678
• Hs Code.: 2933990090
• Mol file: 840488-85-9.mol

Synonyms:6-CHLOROPYRIDAZINE-3-CARBOXYLIC ACID (2-CYCLOPROPYL-ETHYL)AMIDE;N-(2-Cyclopropylethyl)-6-chloropyridazine-3-carboxamide;3-Pyridazinecarboxamide,6-chloro-N-(2-cyclopropylethyl);

Chemical Property of 6-chloro-N-(2-cyclopropylethyl)pyridazine-3-carboxaMide

Chemical Property:

• PSA: 54.88000
• LogP: 2.05080

Purity/Quality:

99% ^*data from raw suppliers

6-Chloro-N-(2-cyclopropylethyl)-pyridazine-3-carboxamide >97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 6-chloro-N-(2-cyclopropylethyl)pyridazine-3-carboxaMide

There total 5 articles about 6-chloro-N-(2-cyclopropylethyl)pyridazine-3-carboxaMide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

6-chloro-pyridazine-3-carboxylic acid (5096-73-1) + 2-(cyclopropyl)ethylamine (62893-54-3) → 6-chloropyridazine-3-carboxylic acid (2-cyclopropylethyl)amide (840488-85-9)

Guidance literature:

6-chloro-pyridazine-3-carboxylic acid; With benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; N-ethyl-N,N-diisopropylamine; In dichloromethane; for 0.25h;

2-(cyclopropyl)ethylamine; In dichloromethane; at 20 ℃; for 36h;

Reference yield:

2-(cyclopropyl)ethylamine (62893-54-3) + 6-chloro-pyridazine-3-carbonyl chloride (6531-04-0) → 6-chloropyridazine-3-carboxylic acid (2-cyclopropylethyl)amide (840488-85-9)

Guidance literature:

With triethylamine; In dichloromethane; at 0 ℃; for 0.75h;

Reference yield:

6-chloro-pyridazine-3-carboxylic acid (5096-73-1) → 6-chloropyridazine-3-carboxylic acid (2-cyclopropylethyl)amide (840488-85-9)

Guidance literature:

Multi-step reaction with 2 steps

1: thionyl chloride; N,N-dimethyl-formamide / chloroform / 11 h / Reflux

2: triethylamine / dichloromethane / 0.5 h / 0 - 20 °C

With thionyl chloride; triethylamine; N,N-dimethyl-formamide; In dichloromethane; chloroform;

DOI:10.1021/jm301661h

upstream raw materials:

6-chloro-pyridazine-3-carboxylic acid

2-(cyclopropyl)ethylamine

6-chloro-pyridazine-3-carbonyl chloride

2-cyclopropylacetonitrile

Downstream raw materials:

6-[4-(4-Fluorophenyl)-piperazin-1-yl]-pyridazine-3-carboxylic acid (2-cyclopropylethyl)amide

6-[4-(2-trifluoromethylbenzoyl)piperazin-1-yl]pyridazine-3-carboxylic acid (2-cyclopropylethyl)amide

6-[4-(2-cyanobenzoyl)piperazin-1-yl]-pyridazine-3-carboxylic acid (2-cyclopropylethyl)amide

6-[4-(2-dimethylaminobenzoyl)piperazin-1-yl]pyridazine-3-carboxylic acid (2-cyclopropylethyl)amide