3-Methyl-2,5-diphenylfuran

Base Information

• Chemical Name: 3-Methyl-2,5-diphenylfuran
• CAS No.: 84302-11-4
• Molecular Formula: C17H14O
• Molecular Weight: 234.298
• DSSTox Substance ID: DTXSID30539595
• Nikkaji Number: J3.270.290B
• Wikidata: Q82415376
• Mol file: 84302-11-4.mol

Synonyms:3-Methyl-2,5-diphenylfuran;84302-11-4;SCHEMBL10205941;DTXSID30539595

Chemical Property of 3-Methyl-2,5-diphenylfuran

Chemical Property:

• XLogP3: 4.7
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 2
• Exact Mass: 234.104465066
• Heavy Atom Count: 18
• Complexity: 250

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CC1=C(OC(=C1)C2=CC=CC=C2)C3=CC=CC=C3

Technology Process of 3-Methyl-2,5-diphenylfuran

There total 34 articles about 3-Methyl-2,5-diphenylfuran which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

2-methyl-1,4-diphenyl-3-buta-2,3-dien-1-one (1139768-51-6) → 3-methyl-2,5-diphenylfuran (84302-11-4)

Guidance literature:

With tris(trifluoromethanesulfonyl)methide potassium salt; C₄₂H₅₃AuClO₄P; silver trifluoromethanesulfonate; In chloroform-d1; at 20 ℃; for 7h; Time; Reagent/catalyst; Sonication; Enzymatic reaction;

DOI:10.1002/anie.201310239

Reference yield: 95.0%

styrene (100-42-5,25038-60-2,25247-68-1,28213-80-1,28325-75-9,79637-11-9,9003-53-6) + 1-phenyl-propan-1-one (93-55-0) → 3-methyl-2,5-diphenylfuran (84302-11-4)

Guidance literature:

With copper dichloride; In N,N-dimethyl-formamide; at 120 ℃; for 16h; Reagent/catalyst; Solvent; regioselective reaction; Catalytic behavior;

DOI:10.1021/acs.joc.7b00476

Reference yield: 92.0%

3-iodo-2,5-diphenylfuran (177742-60-8) + methyl iodide (74-88-4) → 3-methyl-2,5-diphenylfuran (84302-11-4)

Guidance literature:

With n-butyllithium; In tetrahydrofuran; at -78 ℃;

DOI:10.1039/CC9960001007

upstream raw materials:

(Z)-2-methyl-1,4-diphenylbut-2-ene-1,4-dione

(E)-2-methyl-1,4-diphenylbut-2-ene-1,4-dione

Lawessons reagent

2-methyl-1,4-diphenylbutane-1,4-dione

Downstream raw materials:

3-bromomethyl-4-methyl-2,5-diphenyl-furan

3-bromo-4-methyl-2,5-diphenyl-furan

(Z)-2-methyl-1,4-diphenylbut-2-ene-1,4-dione

3-bromo-4-bromomethyl-2,5-bis-(4-bromo-phenyl)-furan