2'-Hydroxy-2,4,4'-trimethoxychalcone

Base Information

Chemical Name:2'-Hydroxy-2,4,4'-trimethoxychalcone
CAS No.:84426-23-3
Molecular Formula:C₁₈H₁₈O₅
Molecular Weight:314.338
Hs Code.:
DSSTox Substance ID:DTXSID901345743
Nikkaji Number:J1.420.665E
Metabolomics Workbench ID:169788
ChEMBL ID:CHEMBL260624

Synonyms:84426-23-3;2'-HYDROXY-2,4,4'-TRIMETHOXYCHALCONE;(E)-3-(2,4-dimethoxyphenyl)-1-(2-hydroxy-4-methoxyphenyl)prop-2-en-1-one;(2E)-3-(2,4-dimethoxyphenyl)-1-(2-hydroxy-4-methoxyphenyl)prop-2-en-1-one;Flavonid, 5a;MLS001048850;SCHEMBL634357;CHEMBL260624;BDBM93434;ZTIPWOFLPVWZDX-WEVVVXLNSA-N;DTXSID901345743;HMS2269P17;STK888602;AKOS002181895;SMR000387058;CS-0332572;MLS001048850-02;VU0254750-3;2'-Hydroxy-2,4,4'-trimethoxychalcone, AldrichCPR;F3139-0675;2-Propen-1-one, 3-(2,4-dimethoxyphenyl)-1-(2-hydroxy-4-methoxyphenyl)-;3-(2,4-dimethoxyphenyl)-1-(2-hydroxy-4-methoxyphenyl)prop-2-en-1-one

Suppliers and Price of 2'-Hydroxy-2,4,4'-trimethoxychalcone

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 2 raw suppliers

Chemical Property of 2'-Hydroxy-2,4,4'-trimethoxychalcone

Chemical Property:

PSA：64.99000
LogP:3.31410
XLogP3:3.8
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:6
Exact Mass:314.11542367
Heavy Atom Count:23
Complexity:408

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:COC1=CC(=C(C=C1)C(=O)C=CC2=C(C=C(C=C2)OC)OC)O
Isomeric SMILES:COC1=CC(=C(C=C1)C(=O)/C=C/C2=C(C=C(C=C2)OC)OC)O

Technology Process of 2'-Hydroxy-2,4,4'-trimethoxychalcone

There total 7 articles about 2'-Hydroxy-2,4,4'-trimethoxychalcone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 552-41-0
1-(2-hydroxy-4-methoxyphenyl)ethanone

: 613-45-6
2,4-Dimethoxybenzaldehyde

: 36685-67-3,84426-23-3
(E)-1-(2-hydroxy-4-methoxyphenyl)-3-(2,4-dimethoxyphenyl)prop-2-en-1-one

Guidance literature:: With potassium hydroxide; In ethanol; at 20 ℃; for 16h;
DOI:10.1021/acs.jnatprod.6b00350

Reference yield: 27.0%

: 79004-62-9
RL334

: 36685-67-3,84426-23-3
(E)-1-(2-hydroxy-4-methoxyphenyl)-3-(2,4-dimethoxyphenyl)prop-2-en-1-one

Guidance literature:: With sodium thioethylate; In N,N-dimethyl-formamide; for 8h; Heating;
DOI:10.1002/ejoc.200400032

Reference yield:

: 20469-63-0
1-iodo-2,4-dimethoxybenzene

: 36685-67-3,84426-23-3
(E)-1-(2-hydroxy-4-methoxyphenyl)-3-(2,4-dimethoxyphenyl)prop-2-en-1-one

Guidance literature:: Multi-step reaction with 2 steps

1: 75 percent / Et₃N; PPh₃ / Pd(OAc)2 / acetonitrile / 5 h / Heating

2: 27 percent / EtSNa / dimethylformamide / 8 h / Heating

With triethylamine; triphenylphosphine; sodium thioethylate; palladium diacetate; In N,N-dimethyl-formamide; acetonitrile; 1: Heck coupling;
DOI:10.1002/ejoc.200400032