1-(3,4-DICHLOROPHENYL)CYCLOBUTANECARBOXYLIC ACID

Base Information

• Chemical Name: 1-(3,4-DICHLOROPHENYL)CYCLOBUTANECARBOXYLIC ACID
• CAS No.: 84485-58-5
• Molecular Formula: C11H10Cl2O2
• Molecular Weight: 245.10200
• Hs Code.: 2916399090
• Mol file: 84485-58-5.mol

Synonyms:

Chemical Property of 1-(3,4-DICHLOROPHENYL)CYCLOBUTANECARBOXYLIC ACID

Chemical Property:

• PSA: 37.30000
• LogP: 3.49970

Purity/Quality:

98% ^*data from raw suppliers

1-(3,4-DICHLOROPHENYL)CYCLOBUTANE-1-CARBOXYLIC ACID 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-(3,4-DICHLOROPHENYL)CYCLOBUTANECARBOXYLIC ACID

There total 3 articles about 1-(3,4-DICHLOROPHENYL)CYCLOBUTANECARBOXYLIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

1-(3,4-dichlorophenyl)-1-cyclobutanecarbonitrile (84467-19-6) → 1-(3,4-dichlorophenyl)-1-cyclobutanecarboxylic acid (84485-58-5)

Guidance literature:

With potassium hydroxide; In ethylene glycol; for 10h; Heating;

DOI:10.1023/A:1013728105186

Reference yield:

3,4-dichloro-benzeneacetonitrile (3218-49-3) → 1-(3,4-dichlorophenyl)-1-cyclobutanecarboxylic acid (84485-58-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 47 percent / triethylbenzylammonium chloride; NaOH / H₂O / 2 h / 55 - 75 °C

2: 62 percent / KOH / ethane-1,2-diol / 10 h / Heating

With potassium hydroxide; sodium hydroxide; N-benzyl-N,N,N-triethylammonium chloride; In water; ethylene glycol;

DOI:10.1023/A:1013728105186

Reference yield:

→ 1-(3,4-dichlorophenyl)-1-cyclobutanecarbonitrile (84467-19-6) + 1-(3,4-dichlorophenyl)-1-cyclobutanecarboxylic acid (84485-58-5)

Guidance literature:

upstream raw materials:

1-(3,4-dichlorophenyl)-1-cyclobutanecarbonitrile

3,4-dichloro-benzeneacetonitrile

Downstream raw materials:

1-(1-(3,4-dichlorophenyl)cyclobutyl)-N,N-dimethylmethanamine

1-(3,4-dichloro-phenyl)-cyclobutanecarbonyl chloride

Refernces

• 1、 Akopyan,Martirosyan,Mndzhoyan,Ter-Zakharyan,Kazaryan,Aleksanyan. "Synthesis and antimicrobial properties of 1-(3,4-dichlorophenyl)cycloalkyl-1-penicillins and cephalosporins". . p. 421 - 423. Retrieved 2007/10/03.