1-(3,4-dichloro-phenyl)-cyclobutanecarbonyl chloride

Base Information

• Chemical Name: 1-(3,4-dichloro-phenyl)-cyclobutanecarbonyl chloride
• CAS No.: 151157-35-6
• Molecular Formula: C₁₁H₉Cl₃O
• Molecular Weight: 263.551
• Mol file: 151157-35-6.mol

Synonyms:

Chemical Property of 1-(3,4-dichloro-phenyl)-cyclobutanecarbonyl chloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(3,4-dichloro-phenyl)-cyclobutanecarbonyl chloride

There total 3 articles about 1-(3,4-dichloro-phenyl)-cyclobutanecarbonyl chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-(3,4-dichlorophenyl)-1-cyclobutanecarboxylic acid (84485-58-5) → 1-(3,4-dichloro-phenyl)-cyclobutanecarbonyl chloride (151157-35-6)

Guidance literature:

With thionyl chloride; In benzene; for 8h; Heating;

DOI:10.1023/A:1013728105186

Reference yield:

3,4-dichloro-benzeneacetonitrile (3218-49-3) → 1-(3,4-dichloro-phenyl)-cyclobutanecarbonyl chloride (151157-35-6)

Guidance literature:

Multi-step reaction with 3 steps

1: 47 percent / triethylbenzylammonium chloride; NaOH / H₂O / 2 h / 55 - 75 °C

2: 62 percent / KOH / ethane-1,2-diol / 10 h / Heating

3: SOCl₂ / benzene / 8 h / Heating

With potassium hydroxide; sodium hydroxide; thionyl chloride; N-benzyl-N,N,N-triethylammonium chloride; In water; ethylene glycol; benzene;

DOI:10.1023/A:1013728105186

Reference yield:

1-(3,4-dichlorophenyl)-1-cyclobutanecarbonitrile (84467-19-6) → 1-(3,4-dichloro-phenyl)-cyclobutanecarbonyl chloride (151157-35-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 62 percent / KOH / ethane-1,2-diol / 10 h / Heating

2: SOCl₂ / benzene / 8 h / Heating

With potassium hydroxide; thionyl chloride; In ethylene glycol; benzene;

DOI:10.1023/A:1013728105186

upstream raw materials:

1-(3,4-dichlorophenyl)-1-cyclobutanecarboxylic acid

3,4-dichloro-benzeneacetonitrile

1-(3,4-dichlorophenyl)-1-cyclobutanecarbonitrile

Refernces