1-(3-Fluoro-5-trifluoroMethylpyridin-2-yl)piperazine

Base Information

• Chemical Name: 1-(3-Fluoro-5-trifluoroMethylpyridin-2-yl)piperazine
• CAS No.: 845616-81-1
• Molecular Formula: C10H11F4N3
• Molecular Weight: 249.211
• Hs Code.: 2933399990
• Mol file: 845616-81-1.mol

Synonyms:1-(3-Fluoro-5-trifluoroMethylpyridin-2-yl)piperazine;1-[3-fluoro-5-(trifluoromethyl)-2-pyridinyl]piperazine;1-(3-fluoro-5-trifluoromethyl-pyridin-2-yl)-piperazine;

Chemical Property of 1-(3-Fluoro-5-trifluoroMethylpyridin-2-yl)piperazine

Chemical Property:

• Boiling Point: 308.9±42.0 °C(Predicted)
• PKA: 8.24±0.10(Predicted)
• PSA: 28.16000
• Density: 1.320±0.06 g/cm3(Predicted)
• LogP: 2.04290

Purity/Quality:

97% ^*data from raw suppliers

1-(3-Fluoro-5-trifluoromethylpyridin-2-yl)piperazine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-(3-Fluoro-5-trifluoroMethylpyridin-2-yl)piperazine

There total 4 articles about 1-(3-Fluoro-5-trifluoroMethylpyridin-2-yl)piperazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.3%

piperazine (110-85-0) + 2,3-difluoro-5-(trifluoromethyl)pyridine (89402-42-6) → 1-(3-fluoro-5-(trifluoromethyl)pyridin-2-yl)piperazine (845616-81-1)

Guidance literature:

In tetrahydrofuran; at 0 - 20 ℃; for 1h;

Reference yield: 99.0%

4-(3-fluoro-5-trifluoromethylpyridin-2-yl)piperazine-1-carboxylic acid tert-butyl ester (897376-76-0) → 1-(3-fluoro-5-(trifluoromethyl)pyridin-2-yl)piperazine (845616-81-1)

Guidance literature:

4-(3-fluoro-5-trifluoromethylpyridin-2-yl)piperazine-1-carboxylic acid tert-butyl ester; With trifluoroacetic acid; In dichloromethane; for 16h; Heating / reflux;

With sodium hydroxide; In dichloromethane; water;

Reference yield: 78.0%

piperazine (110-85-0) + 2-chloro-3-nitro-5-(trifluoromethyl)pyridine (72587-15-6) → 1-(3-fluoro-5-(trifluoromethyl)pyridin-2-yl)piperazine (845616-81-1)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In dimethyl sulfoxide; at 20 ℃; for 2h;

upstream raw materials:

4-(3-fluoro-5-trifluoromethylpyridin-2-yl)piperazine-1-carboxylic acid tert-butyl ester

piperazine

2-chloro-3-nitro-5-(trifluoromethyl)pyridine

2,3-difluoro-5-(trifluoromethyl)pyridine

Downstream raw materials:

C₂₀H₂₁F₄N₃O₄S

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