2,3-Difluoro-5-(trifluoromethyl)pyridine

Base Information

• Chemical Name: 2,3-Difluoro-5-(trifluoromethyl)pyridine
• CAS No.: 89402-42-6
• Molecular Formula: C6H2F5N
• Molecular Weight: 183.081
• Hs Code.: 2933399090
• European Community (EC) Number: 677-278-0
• DSSTox Substance ID: DTXSID10540285
• Nikkaji Number: J417.238H
• Wikidata: Q72464387
• Mol file: 89402-42-6.mol

Synonyms:2,3-Difluoro-5-(trifluoromethyl)pyridine;89402-42-6;2,3-Difluoro-5-trifluoromethylpyridine;MFCD04972837;Pyridine, 2,3-difluoro-5-(trifluoromethyl)-;2,3-difluoro-5-trifluoromethyl-pyridine;EC 677-278-0;SCHEMBL609041;DTXSID10540285;AKOS005063715;AM87384;DS-9055;SB17911;AC-24489;SY032271;2,3-di-fluoro-5-(trifluoromethyl)pyridine;2,3-difluoro-5-(trifluoromethyl)-pyridine;CS-0007626;D4623;NS00007505;EN300-393323;A843187;2,3-Difluoro-5-(trifluoromethyl)pyridine, AldrichCPR

Chemical Property of 2,3-Difluoro-5-(trifluoromethyl)pyridine

Chemical Property:

• Vapor Pressure: 18.093mmHg at 25°C
• Melting Point: -20 °C
• Refractive Index: 1.387
• Boiling Point: 120.677 °C at 760 mmHg
• PKA: -5.28±0.20(Predicted)
• Flash Point: 26.785 °C
• PSA: 12.89000
• Density: 1.469 g/cm³
• LogP: 2.37860
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• XLogP3: 2.3
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 6
• Rotatable Bond Count: 0
• Exact Mass: 183.01073988
• Heavy Atom Count: 12
• Complexity: 157

Purity/Quality:

99.9% ^*data from raw suppliers

2,3-Difluoro-5-(trifluoromethyl)pyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi,T
• Statements: 10-36-25
• Safety Statements: 16-45-26

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=C(C=NC(=C1F)F)C(F)(F)F
• Description: 2,3-Difluoro-5-(trifluoromethyl)pyridine is a useful research chemical.
• Uses: 2,3-Difluoro-5-(trifluoroMethyl)pyridine is a heterocyclic compound and can be used as a pharmaceutical intermediate.

Technology Process of 2,3-Difluoro-5-(trifluoromethyl)pyridine

There total 6 articles about 2,3-Difluoro-5-(trifluoromethyl)pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 47.6%

2,3-dichloro-5-trifluoromethylpyridine (69045-84-7) → 2,3-difluoro-5-(trifluoromethyl)pyridine (89402-42-6)

Guidance literature:

With potassium carbonate; cesium fluoride; In dimethyl sulfoxide; at 80 - 110 ℃; for 48h; Inert atmosphere;

Reference yield:

potassium carbonate (584-08-7) + 2-fluoro-3-chloro-5-(trifluoromethyl)pyridine (72537-17-8) → 2,3-difluoro-5-(trifluoromethyl)pyridine (89402-42-6)

Guidance literature:

With cesium fluoride; In dimethyl sulfoxide;

Reference yield:

2-chloro-3-fluoro-5-(trifluoromethyl)pyridine (72600-67-0) → 2,3-difluoro-5-(trifluoromethyl)pyridine (89402-42-6)

Guidance literature:

With caesium fluoride; potassium fluoride; In sulfolane;

upstream raw materials:

potassium carbonate

2-fluoro-3-chloro-5-(trifluoromethyl)pyridine

carbon dioxide

2-chloro-3-fluoro-5-(trifluoromethyl)pyridine

Downstream raw materials:

4-(5-(trifluoromethyl)-3-fluoro-2-pyridyloxy)benzaldehyde

2,3-dimethoxy-5-(trifluoromethyl)pyridine

(+)-2-[4-(3-fluoro-5-trifluoromethylpyridin-2-yloxy)-phenoxy]-propionic acid methyl ester

disodium resorcinolate