1-(Triphenylmethyl)aziridine-2-carboxylic acid

Base Information

• Chemical Name: 1-(Triphenylmethyl)aziridine-2-carboxylic acid
• CAS No.: 84771-33-5
• Molecular Formula: C22H19NO2
• Molecular Weight: 329.398
• DSSTox Substance ID: DTXSID30603240
• Mol file: 84771-33-5.mol

Synonyms:1-tritylaziridine-2-carboxylic acid;1-(Triphenylmethyl)aziridine-2-carboxylic acid;84771-33-5;856629-10-2;(2R)-1-(triphenylmethyl)aziridine-2-carboxylic acid;SCHEMBL991996;SCHEMBL4047420;DTXSID30603240;BXSIPZGNIBVSLK-UHFFFAOYSA-N;1-tritylaziridine-2-carboxylicacid;1-Trityl-aziridine-2-carboxylic acid

Chemical Property of 1-(Triphenylmethyl)aziridine-2-carboxylic acid

Chemical Property:

• PSA: 40.31000
• LogP: 3.68520
• XLogP3: 2.1
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 5
• Exact Mass: 329.141578849
• Heavy Atom Count: 25
• Complexity: 413

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: C1C(N1C(C2=CC=CC=C2)(C3=CC=CC=C3)C4=CC=CC=C4)C(=O)O

Technology Process of 1-(Triphenylmethyl)aziridine-2-carboxylic acid

There total 3 articles about 1-(Triphenylmethyl)aziridine-2-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

methyl (2S)-N-tritylaziridine-2-carboxylate (75154-68-6) → (2S)-1-trityl-aziridine-2-carboxylic acid (84771-33-5)

Guidance literature:

With water; sodium hydroxide; lithium hydroxide; In tetrahydrofuran; at 0 ℃; for 2h;

DOI:10.1071/CH13464

Reference yield: 79.0%

benzyl (-)-(2S)-1-trityl-aziridine-2-carboxylate (67413-25-6) → (2S)-1-trityl-aziridine-2-carboxylic acid (84771-33-5)

Guidance literature:

With hydrogen; palladium on activated charcoal; In 1,4-dioxane; for 2h; Ambient temperature;

DOI:10.1016/S0040-4020(01)80847-4

Reference yield:

benzyl 3-hydroxy-2-(tritylamino)propanoate (67553-36-0) → (2S)-1-trityl-aziridine-2-carboxylic acid (84771-33-5)

Guidance literature:

Multi-step reaction with 2 steps

2: 79 percent / H₂ / Pd/C / dioxane / 2 h / Ambient temperature

With hydrogen; palladium on activated charcoal; In 1,4-dioxane;

DOI:10.1016/S0040-4020(01)80847-4

upstream raw materials:

benzyl (-)-(2S)-1-trityl-aziridine-2-carboxylate

methyl (2S)-N-tritylaziridine-2-carboxylate

benzyl 3-hydroxy-2-(tritylamino)propanoate

Downstream raw materials:

C₃₇H₃₉N₃O₅

benzyl (-)-(2S)-1-trityl-aziridine-2-carboxylate