67553-36-0Relevant articles and documents
Oligo(serine ester) Charge-Altering Releasable Transporters: Organocatalytic Ring-Opening Polymerization and their Use for in Vitro and in Vivo mRNA Delivery
Benner, Nancy L.,McClellan, Rebecca L.,Turlington, Christopher R.,Haabeth, Ole A. W.,Waymouth, Robert M.,Wender, Paul A.
, p. 8416 - 8421 (2019)
RNA technology is transforming life science research and medicine, but many applications are limited by the accessibility, cost, efficacy, and tolerability of delivery systems. Here we report the first members of a new class of dynamic RNA delivery vector
Genetic encoding of 2-aryl-5-carboxytetrazole-based protein photo-cross-linkers
Tian, Yulin,Lin, Qing
supporting information, p. 4449 - 4452 (2018/05/03)
Three γ-heteroatom-substituted N-methylpyrroletetrazole-lysines (mPyTXKs) were synthesized and subsequently incorporated into proteins site-specifically via genetic code expansion. The γ-seleno-substituted derivative, mPyTSeK, showed excellent incorporati
Selective Targeting of the TPX2 Site of Importin-α Using Fragment-Based Ligand Design
Holvey, Rhian S.,Valkov, Eugene,Neal, David,Stewart, Murray,Abell, Chris
supporting information, p. 1232 - 1239 (2015/07/07)
Protein-protein interactions are difficult therapeutic targets, and inhibiting pathologically relevant interactions without disrupting other essential ones presents an additional challenge. Herein we report how this might be achieved for the potential ant
Aziridine ring opening as regio- and stereoselective access to O-glycosyl amino acids and their transformation into O-glycopeptide mimetics
Schaefer, Andreas,Henkensmeier, Dirk,Kroeger, Lars,Thiem, Joachim
body text, p. 902 - 909 (2009/09/25)
Glycosyl amino acid mimetics of the typical GalNAc-(1→O)-Ser/Thr motif of O-glycopeptides were synthesised. Starting from galactose a 1,5-anhydro derivative could be obtained and regio- and stereoselectively coupled to serine- or threonine-derived aziridine compounds, respectively. The corresponding Fmoc derivatives could be used to prepare two 13-mer glycopeptides of the mucin MUC1 carrying instead of Ser-2 or Th-5, the corresponding O-glcycosyl amino acid mimetics.